Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran
Acute respiratory tract infection (ARTI) remains a major health threat to children under five, contributing to significant morbidity and mortality worldwide. According to the World Health Organization (WHO), ARTI leads to the hospitalization of over 12 million children annually, with approximately o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1396142/full |
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| author | Mahnaz Ramzali Saeed Samadizadeh Mohsen Ebrahimi Leila Barati Britt Nakstad Britt Nakstad Alireza Tahamtan Alireza Tahamtan |
| author_facet | Mahnaz Ramzali Saeed Samadizadeh Mohsen Ebrahimi Leila Barati Britt Nakstad Britt Nakstad Alireza Tahamtan Alireza Tahamtan |
| author_sort | Mahnaz Ramzali |
| collection | DOAJ |
| description | Acute respiratory tract infection (ARTI) remains a major health threat to children under five, contributing to significant morbidity and mortality worldwide. According to the World Health Organization (WHO), ARTI leads to the hospitalization of over 12 million children annually, with approximately one million fatalities, one-third of which occur in low-income countries. The respiratory tract hosts diverse microorganisms, among which pathogenic viruses and bacteria are the leading causes of ARTI. Several risk factors—including age, gender, living conditions, seasonality, and underlying diseases—can influence disease severity. Documenting detailed case series that highlight the clinical characteristics and outcomes of pediatric ARTI, particularly in children with complex underlying conditions, is essential for understanding its impact and guiding clinical decision-making. This manuscript presents a case series of eight pediatric patients from Taleghani Children's Hospital in Gorgan, northern Iran, who tragically succumbed to respiratory viral infections, offering insights into the challenges of managing severe ARTI in children. |
| format | Article |
| id | doaj-art-e0d21b76543c488ab69a2ebdc10f6b7b |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-e0d21b76543c488ab69a2ebdc10f6b7b2025-08-20T02:28:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-05-011310.3389/fped.2025.13961421396142Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in IranMahnaz Ramzali0Saeed Samadizadeh1Mohsen Ebrahimi2Leila Barati3Britt Nakstad4Britt Nakstad5Alireza Tahamtan6Alireza Tahamtan7Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, IranWellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, United KingdomNeonatal and Children’s Hospital Research Centre, Golestan University of Medical Sciences, Gorgan, IranNeonatal and Children’s Hospital Research Centre, Golestan University of Medical Sciences, Gorgan, IranDepartment of Pediatric and Adolescent Health, University of Botswana, Gaborone, BotswanaDivision of Paediatric and Adolescent Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, IranInfectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, IranAcute respiratory tract infection (ARTI) remains a major health threat to children under five, contributing to significant morbidity and mortality worldwide. According to the World Health Organization (WHO), ARTI leads to the hospitalization of over 12 million children annually, with approximately one million fatalities, one-third of which occur in low-income countries. The respiratory tract hosts diverse microorganisms, among which pathogenic viruses and bacteria are the leading causes of ARTI. Several risk factors—including age, gender, living conditions, seasonality, and underlying diseases—can influence disease severity. Documenting detailed case series that highlight the clinical characteristics and outcomes of pediatric ARTI, particularly in children with complex underlying conditions, is essential for understanding its impact and guiding clinical decision-making. This manuscript presents a case series of eight pediatric patients from Taleghani Children's Hospital in Gorgan, northern Iran, who tragically succumbed to respiratory viral infections, offering insights into the challenges of managing severe ARTI in children.https://www.frontiersin.org/articles/10.3389/fped.2025.1396142/fullcase seriesviral respiratory infectionspediatric failureacute respiratory tract infectionIran |
| spellingShingle | Mahnaz Ramzali Saeed Samadizadeh Mohsen Ebrahimi Leila Barati Britt Nakstad Britt Nakstad Alireza Tahamtan Alireza Tahamtan Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran Frontiers in Pediatrics case series viral respiratory infections pediatric failure acute respiratory tract infection Iran |
| title | Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran |
| title_full | Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran |
| title_fullStr | Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran |
| title_full_unstemmed | Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran |
| title_short | Case Report: Pediatric respiratory viral infection failure: a case series of eight fatalities in children under 5 years old in Iran |
| title_sort | case report pediatric respiratory viral infection failure a case series of eight fatalities in children under 5 years old in iran |
| topic | case series viral respiratory infections pediatric failure acute respiratory tract infection Iran |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1396142/full |
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