Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State
Background. The diagnostic usefulness of electrophysiological methods in assessing disorders of consciousness (DoC) remains to be established on an individual patient level, and there is need to determine what constitutes robust experimental paradigm to elicit electrophysiological indices of covert...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/145913 |
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| author | Solveig L. Hauger Caroline Schnakers Stein Andersson Frank Becker Torgeir Moberget Joseph T. Giacino Anne-Kristine Schanke Marianne Løvstad |
| author_facet | Solveig L. Hauger Caroline Schnakers Stein Andersson Frank Becker Torgeir Moberget Joseph T. Giacino Anne-Kristine Schanke Marianne Løvstad |
| author_sort | Solveig L. Hauger |
| collection | DOAJ |
| description | Background. The diagnostic usefulness of electrophysiological methods in assessing disorders of consciousness (DoC) remains to be established on an individual patient level, and there is need to determine what constitutes robust experimental paradigm to elicit electrophysiological indices of covert cognitive capacity. Objectives. Two tasks encompassing active and passive conditions were explored in an event-related potentials (ERP) study. The task robustness was studied in healthy controls, and their utility to detect covert signs of command-following on an individual patient level was investigated in patients in a minimally conscious state (MCS). Methods. Twenty healthy controls and 20 MCS patients participated. The active tasks included (1) listening for a change of pitch in the subject’s own name (SON) and (2) counting SON, both contrasted to passive conditions. Midline ERPs are reported. Results. A larger P3 response was detected in the counting task compared to active listening to pitch change in the healthy controls. On an individual level, the counting task revealed a higher rate of responders among both healthy subjects and MCS patients. Conclusion. ERP paradigms involving actively counting SON represent a robust paradigm in probing for volitional cognition in minimally conscious patients and add important diagnostic information in some patients. |
| format | Article |
| id | doaj-art-e0d215d19c214656a890b50cde0f0b97 |
| institution | OA Journals |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-e0d215d19c214656a890b50cde0f0b972025-08-20T02:21:29ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/145913145913Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious StateSolveig L. Hauger0Caroline Schnakers1Stein Andersson2Frank Becker3Torgeir Moberget4Joseph T. Giacino5Anne-Kristine Schanke6Marianne Løvstad7Department of Research, Sunnaas Rehabilitation Hospital, 1450 Nesoddtangen, NorwayDepartment of Psychology and Neurosurgery, University of California, Los Angeles, CA 90095-1563, USADepartment of Psychology, University of Oslo, Postboks 1094 Blindern, 0317 Oslo, NorwayDepartment of Research, Sunnaas Rehabilitation Hospital, 1450 Nesoddtangen, NorwayNorwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Postboks 4953 Nydalen, 0424 Oslo, NorwayDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, 300 First Avenue, Charlestown, MA 02129, USADepartment of Research, Sunnaas Rehabilitation Hospital, 1450 Nesoddtangen, NorwayDepartment of Research, Sunnaas Rehabilitation Hospital, 1450 Nesoddtangen, NorwayBackground. The diagnostic usefulness of electrophysiological methods in assessing disorders of consciousness (DoC) remains to be established on an individual patient level, and there is need to determine what constitutes robust experimental paradigm to elicit electrophysiological indices of covert cognitive capacity. Objectives. Two tasks encompassing active and passive conditions were explored in an event-related potentials (ERP) study. The task robustness was studied in healthy controls, and their utility to detect covert signs of command-following on an individual patient level was investigated in patients in a minimally conscious state (MCS). Methods. Twenty healthy controls and 20 MCS patients participated. The active tasks included (1) listening for a change of pitch in the subject’s own name (SON) and (2) counting SON, both contrasted to passive conditions. Midline ERPs are reported. Results. A larger P3 response was detected in the counting task compared to active listening to pitch change in the healthy controls. On an individual level, the counting task revealed a higher rate of responders among both healthy subjects and MCS patients. Conclusion. ERP paradigms involving actively counting SON represent a robust paradigm in probing for volitional cognition in minimally conscious patients and add important diagnostic information in some patients.http://dx.doi.org/10.1155/2015/145913 |
| spellingShingle | Solveig L. Hauger Caroline Schnakers Stein Andersson Frank Becker Torgeir Moberget Joseph T. Giacino Anne-Kristine Schanke Marianne Løvstad Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State Behavioural Neurology |
| title | Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State |
| title_full | Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State |
| title_fullStr | Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State |
| title_full_unstemmed | Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State |
| title_short | Neurophysiological Indicators of Residual Cognitive Capacity in the Minimally Conscious State |
| title_sort | neurophysiological indicators of residual cognitive capacity in the minimally conscious state |
| url | http://dx.doi.org/10.1155/2015/145913 |
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