Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles
Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines. Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/45130/43759 |
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| author | O. A. Suhak O. I. Panasenko Ye. G. Knysh |
| author_facet | O. A. Suhak O. I. Panasenko Ye. G. Knysh |
| author_sort | O. A. Suhak |
| collection | DOAJ |
| description | Aim. Selection, synthesis and biological properties of new compound play major role in creating original medicines.
Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS.
Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds. |
| format | Article |
| id | doaj-art-e0ce9978b5d149a68f3bc98f2e4530ac |
| institution | DOAJ |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-e0ce9978b5d149a68f3bc98f2e4530ac2025-08-20T02:51:03ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-08-012212410.14739/2409-2932.2015.2.45130Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazolesO. A. SuhakO. I. PanasenkoYe. G. KnyshAim. Selection, synthesis and biological properties of new compound play major role in creating original medicines. Methods and results. Therefore, to find new bioactive compounds 3-(alkylthio)-4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles, where R - methyl, ethyl, phenyl, have been synthesized, by alkylation reaction of 4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-thiols with 1-bromobutane, or 1-bromopentane, or 1-bromohexane, 1-bromoheptane, 1-bromooctane, 1-bromononane, 1-bromodekane in the n-butanol medium and their physical-chemical properties have been studied using modern physical-chemical methods of analysis, elemental analysis, IR spectroscopy, and their individuality using HPLC-MS. Conclusion. This suggests the possibility of further studying the biological effect of the synthesized compounds.http://pharmed.zsmu.edu.ua/article/view/45130/437591 2 4-triazolesIR-spectroscopyHPLC-mass SpectrometrySynthesis |
| spellingShingle | O. A. Suhak O. I. Panasenko Ye. G. Knysh Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki 1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis |
| title | Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_full | Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_fullStr | Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_full_unstemmed | Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_short | Synthesis and physical-chemical properties of 3-(alkylthio)-4-R-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazoles |
| title_sort | synthesis and physical chemical properties of 3 alkylthio 4 r 5 thiophen 2 ylmethyl 4h 1 2 4 triazoles |
| topic | 1 2 4-triazoles IR-spectroscopy HPLC-mass Spectrometry Synthesis |
| url | http://pharmed.zsmu.edu.ua/article/view/45130/43759 |
| work_keys_str_mv | AT oasuhak synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles AT oipanasenko synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles AT yegknysh synthesisandphysicalchemicalpropertiesof3alkylthio4r5thiophen2ylmethyl4h124triazoles |