Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature
Glycogenic hepatopathy (GH) is the accumulation of glycogen in the hepatocytes and represents a rare complication in patients with diabetes mellitus (DM), most commonly type 1 DM. We present a case of a 23-year-old woman with a medical history of poorly controlled type 1 DM and gastroesophageal refl...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/9368348 |
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| author | Atinuke Aluko Ikponmwosa Enofe Jacob Burch Julie Yam Nazia Khan |
| author_facet | Atinuke Aluko Ikponmwosa Enofe Jacob Burch Julie Yam Nazia Khan |
| author_sort | Atinuke Aluko |
| collection | DOAJ |
| description | Glycogenic hepatopathy (GH) is the accumulation of glycogen in the hepatocytes and represents a rare complication in patients with diabetes mellitus (DM), most commonly type 1 DM. We present a case of a 23-year-old woman with a medical history of poorly controlled type 1 DM and gastroesophageal reflux disease (GERD) who presented with progressively worsening right-sided abdominal pain. Diagnostic workup resulted in a liver biopsy with hepatocytes that stained heavily for glycogen with no evidence of fibrosis or steatohepatitis. A diagnosis of glycogenic hepatopathy was made, and an aggressive glucose control regimen was implemented leading to resolution of symptoms and improvement in AST, ALT, and ALP. In addition to presenting this rare case, we offer a review of literature and draw important distinctions between glycogenic hepatopathy and other differential diagnoses with the aim of assisting providers in the diagnostic workup and treatment of glycogenic hepatopathy. |
| format | Article |
| id | doaj-art-e0cbc3ca814a4303b0302a3a9182a8b7 |
| institution | OA Journals |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-e0cbc3ca814a4303b0302a3a9182a8b72025-08-20T02:21:30ZengWileyCase Reports in Hepatology2090-65872090-65952020-01-01202010.1155/2020/93683489368348Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the LiteratureAtinuke Aluko0Ikponmwosa Enofe1Jacob Burch2Julie Yam3Nazia Khan4Michigan State University, Department of Internal Medicine, East Lansing, MI, USAMichigan State University, Department of Internal Medicine, East Lansing, MI, USAMichigan State University, Department of Internal Medicine, East Lansing, MI, USAMichigan State University, Gastroenterology Fellowship, East Lansing, MI, USAMichigan State University, Department of Internal Medicine, East Lansing, MI, USAGlycogenic hepatopathy (GH) is the accumulation of glycogen in the hepatocytes and represents a rare complication in patients with diabetes mellitus (DM), most commonly type 1 DM. We present a case of a 23-year-old woman with a medical history of poorly controlled type 1 DM and gastroesophageal reflux disease (GERD) who presented with progressively worsening right-sided abdominal pain. Diagnostic workup resulted in a liver biopsy with hepatocytes that stained heavily for glycogen with no evidence of fibrosis or steatohepatitis. A diagnosis of glycogenic hepatopathy was made, and an aggressive glucose control regimen was implemented leading to resolution of symptoms and improvement in AST, ALT, and ALP. In addition to presenting this rare case, we offer a review of literature and draw important distinctions between glycogenic hepatopathy and other differential diagnoses with the aim of assisting providers in the diagnostic workup and treatment of glycogenic hepatopathy.http://dx.doi.org/10.1155/2020/9368348 |
| spellingShingle | Atinuke Aluko Ikponmwosa Enofe Jacob Burch Julie Yam Nazia Khan Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature Case Reports in Hepatology |
| title | Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature |
| title_full | Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature |
| title_fullStr | Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature |
| title_full_unstemmed | Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature |
| title_short | Hepatocellular Glycogen Accumulation in the Setting of Poorly Controlled Type 1 Diabetes Mellitus: Case Report and Review of the Literature |
| title_sort | hepatocellular glycogen accumulation in the setting of poorly controlled type 1 diabetes mellitus case report and review of the literature |
| url | http://dx.doi.org/10.1155/2020/9368348 |
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