Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments
Abstract Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such as Parkinson's disease, for more than 25 years and heralded the advent of electrical neuromodulation to treat diseases with dysregulated neuronal circuits. DBS is now superseding ablative techniqu...
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| Format: | Article |
| Language: | English |
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Springer Nature
2019-03-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201809575 |
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| author | Martin Jakobs Anton Fomenko Andres M Lozano Karl L Kiening |
| author_facet | Martin Jakobs Anton Fomenko Andres M Lozano Karl L Kiening |
| author_sort | Martin Jakobs |
| collection | DOAJ |
| description | Abstract Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such as Parkinson's disease, for more than 25 years and heralded the advent of electrical neuromodulation to treat diseases with dysregulated neuronal circuits. DBS is now superseding ablative techniques, such as stereotactic radiofrequency lesions. While serendipity has played a role in developing DBS as a therapy, research during the past two decades has shown that electrical neuromodulation is far more than a functional lesion that can be switched on and off. This understanding broadens the field to enable new types of stimulation, clinical indications, and research. This review highlights the complex effects of DBS from the single cell to the neuronal network. Specifically, we examine the electrical, cellular, molecular, and neurochemical mechanisms of DBS as applied to Parkinson's disease and other emerging applications. |
| format | Article |
| id | doaj-art-e0c539c92b674d088f90b17f8bd36ce3 |
| institution | DOAJ |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-e0c539c92b674d088f90b17f8bd36ce32025-08-20T03:06:00ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842019-03-0111411810.15252/emmm.201809575Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developmentsMartin Jakobs0Anton Fomenko1Andres M Lozano2Karl L Kiening3Department of Neurosurgery, University Hospital HeidelbergDivision of Neurosurgery, Toronto Western Hospital, University Health NetworkDivision of Neurosurgery, Toronto Western Hospital, University Health NetworkDepartment of Neurosurgery, University Hospital HeidelbergAbstract Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such as Parkinson's disease, for more than 25 years and heralded the advent of electrical neuromodulation to treat diseases with dysregulated neuronal circuits. DBS is now superseding ablative techniques, such as stereotactic radiofrequency lesions. While serendipity has played a role in developing DBS as a therapy, research during the past two decades has shown that electrical neuromodulation is far more than a functional lesion that can be switched on and off. This understanding broadens the field to enable new types of stimulation, clinical indications, and research. This review highlights the complex effects of DBS from the single cell to the neuronal network. Specifically, we examine the electrical, cellular, molecular, and neurochemical mechanisms of DBS as applied to Parkinson's disease and other emerging applications.https://doi.org/10.15252/emmm.201809575circuitopathiesdeep brain stimulationmovement disordersneuromodulationParkinson's disease |
| spellingShingle | Martin Jakobs Anton Fomenko Andres M Lozano Karl L Kiening Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments EMBO Molecular Medicine circuitopathies deep brain stimulation movement disorders neuromodulation Parkinson's disease |
| title | Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments |
| title_full | Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments |
| title_fullStr | Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments |
| title_full_unstemmed | Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments |
| title_short | Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments |
| title_sort | cellular molecular and clinical mechanisms of action of deep brain stimulation a systematic review on established indications and outlook on future developments |
| topic | circuitopathies deep brain stimulation movement disorders neuromodulation Parkinson's disease |
| url | https://doi.org/10.15252/emmm.201809575 |
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