The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

The anti‐hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ‐dependent inhibition of the AKT pathway

Abstract A variety of drugs targeting monoamine receptors are routinely used in human pharmacology. We assessed the effect of these drugs on the viability of tumor‐initiating cells isolated from patients with glioblastoma. Among the drugs targeting monoamine receptors, we identified prazosin, an α1‐...

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Main Authors: Suzana Assad Kahn, Silvia Lima Costa, Sharareh Gholamin, Ryan T Nitta, Luiz Gustavo Dubois, Marie Fève, Maria Zeniou, Paulo Lucas Cerqueira Coelho, Elias El‐Habr, Josette Cadusseau, Pascale Varlet, Siddhartha S Mitra, Bertrand Devaux, Marie‐Claude Kilhoffer, Samuel H Cheshier, Vivaldo Moura‐Neto, Jacques Haiech, Marie‐Pierre Junier, Hervé Chneiweiss
Format: Article
Language:English
Published: Springer Nature 2016-04-01
Series:EMBO Molecular Medicine
Subjects:
glioma
GL261
rottlerin
sh PKCδ
δV1.1
Online Access:https://doi.org/10.15252/emmm.201505421
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