Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production
Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induce...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/7650978 |
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| author | Rui Zhu Yan-Qing Lei Dong-Chi Zhao |
| author_facet | Rui Zhu Yan-Qing Lei Dong-Chi Zhao |
| author_sort | Rui Zhu |
| collection | DOAJ |
| description | Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinflammatory cytokine productions together with decreased CXCL14 and increased PKM2 expressions in injured lungs. In addition, CXCL14 overexpression downregulated PKM2 expression and attenuated VILI with reduced inflammation. Moreover, the overexpression of PKM2 markedly diminished the protective effects of CXCL14 against VILI as reflected by worsened morphology and increased cytokine production, whereas PKM2 knockdown decreased cytokine production and attenuated VILI. Collectively, these results suggested that CXCL14 overexpression attenuates VILI through the downregulation of PKM2-mediated proinflammatory cytokine production. |
| format | Article |
| id | doaj-art-e0c2a17628864c9d926c30e624bbf61a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e0c2a17628864c9d926c30e624bbf61a2025-08-20T03:25:59ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/76509787650978Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine ProductionRui Zhu0Yan-Qing Lei1Dong-Chi Zhao2Department of Pediatrics, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei 430071, ChinaDepartment of Emergency, Xiangyang No.1 People’s Hospital, Hubei University of Medicine, 15 Jiefang Road, Xiangyang, Hubei 441000, ChinaDepartment of Pediatrics, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei 430071, ChinaVentilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinflammatory cytokine productions together with decreased CXCL14 and increased PKM2 expressions in injured lungs. In addition, CXCL14 overexpression downregulated PKM2 expression and attenuated VILI with reduced inflammation. Moreover, the overexpression of PKM2 markedly diminished the protective effects of CXCL14 against VILI as reflected by worsened morphology and increased cytokine production, whereas PKM2 knockdown decreased cytokine production and attenuated VILI. Collectively, these results suggested that CXCL14 overexpression attenuates VILI through the downregulation of PKM2-mediated proinflammatory cytokine production.http://dx.doi.org/10.1155/2020/7650978 |
| spellingShingle | Rui Zhu Yan-Qing Lei Dong-Chi Zhao Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production Mediators of Inflammation |
| title | Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production |
| title_full | Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production |
| title_fullStr | Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production |
| title_full_unstemmed | Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production |
| title_short | Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production |
| title_sort | overexpression of cxcl14 alleviates ventilator induced lung injury through the downregulation of pkm2 mediated cytokine production |
| url | http://dx.doi.org/10.1155/2020/7650978 |
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