The pre-mRNA splicing modulator pladienolide B inhibits Cryptococcus neoformans germination and growth

The pre-mRNA splicing modulator pladienolide B inhibits Cryptococcus neoformans germination and growth

ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen responsible for life-threatening infections, particularly in immunocompromised individuals. The limitations of current antifungal therapies due to toxicity and the emergence of resistance highlight the need for novel treatment stra...

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Bibliographic Details
Main Authors: Sierra L. Love, Megan C. McKeon, Henrik Vollmer, Joshua C. Paulson, Nanami Oshimura, Olivia Valentine, Sébastien C. Ortiz, Christina M. Hull, Aaron A. Hoskins
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mSphere
Subjects:
C. neoformans
splicing
inhibitor
pre-mRNA
antifungal
Online Access:https://journals.asm.org/doi/10.1128/msphere.00248-25
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