Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock
<b>Background/Objectives:</b> The aim of this study was to investigate the response of interleukin-6 (IL-6) during the first few hours of a patient’s stay in the Intensive Care Unit (ICU) in a sample of critically ill patients with septic shock, compared to healthy subjects as controls....
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2079-9721/12/11/298 |
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| author | Yenifer Gamarra-Morales Jorge Molina-López Felipe-Carlos Santiago-Ruiz Lourdes Herrera-Quintana Héctor Vázquez-Lorente Félix Gascón-Luna Elena Planells |
| author_facet | Yenifer Gamarra-Morales Jorge Molina-López Felipe-Carlos Santiago-Ruiz Lourdes Herrera-Quintana Héctor Vázquez-Lorente Félix Gascón-Luna Elena Planells |
| author_sort | Yenifer Gamarra-Morales |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The aim of this study was to investigate the response of interleukin-6 (IL-6) during the first few hours of a patient’s stay in the Intensive Care Unit (ICU) in a sample of critically ill patients with septic shock, compared to healthy subjects as controls. Additionally, the study examined the association of IL-6 with morbidity and mortality in these patients, as well as its relationship with biomarkers such as lactic acid, C-reactive protein (CRP) and procalcitonin (PCT). <b>Methods:</b> This was a prospective analytical study involving 28 critically ill patients with septic shock, monitored from ICU admission through to their first three days of stay. Demographic data, comorbidities and clinical information, including IL-6 and severity scores, were recorded. <b>Results:</b> IL-6 levels were significantly higher in patients with septic shock compared to healthy subjects (<i>p</i> < 0.001) upon admission. IL-6 levels decreased by the third day of ICU stay (<i>p</i> < 0.005). An association between IL-6 and mortality was observed (areas under the curve 0.826, confidence interval (CI) 95% 0.659−0.994, <i>p</i> < 0.008). Significant correlations between IL-6 and lactic acid (<i>p</i> < 0.009 and <i>p</i> < 0.018) and partial thromboplastin time (<i>p</i> < 0.004 and <i>p</i> < 0.007) were found on the first and third days, respectively. IL-6 was also the correlated with an anion gap at admission to the ICU (<i>p</i> < 0.009). <b>Conclusions:</b> In conclusion, this study suggests that IL-6 could be a valuable marker for early sepsis follow-up in ICU patients, particularly during the first 72 h of hospitalization, providing important prognostic information in patients with septic shock. |
| format | Article |
| id | doaj-art-e0c145164f17406c96f12a68dc405064 |
| institution | OA Journals |
| issn | 2079-9721 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Diseases |
| spelling | doaj-art-e0c145164f17406c96f12a68dc4050642025-08-20T02:08:14ZengMDPI AGDiseases2079-97212024-11-01121129810.3390/diseases12110298Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic ShockYenifer Gamarra-Morales0Jorge Molina-López1Felipe-Carlos Santiago-Ruiz2Lourdes Herrera-Quintana3Héctor Vázquez-Lorente4Félix Gascón-Luna5Elena Planells6Clinical Analysis Unit, Santa Ana Hospital, 18600 Motril, SpainFaculty of Education, Psychology and Sports Sciences, University of Huelva, 21007 Huelva, SpainIntensive Care Unit, Santa Ana Hospital, 18600 Motril, SpainDepartment of Physiology, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, 18071 Granada, SpainDepartment of Physiology, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, 18071 Granada, SpainClinical Analysis Unit, Valle de los Pedroches Hospital, 14400 Córdoba, SpainDepartment of Physiology, School of Pharmacy, Institute of Nutrition and Food Technology “José Mataix”, University of Granada, 18071 Granada, Spain<b>Background/Objectives:</b> The aim of this study was to investigate the response of interleukin-6 (IL-6) during the first few hours of a patient’s stay in the Intensive Care Unit (ICU) in a sample of critically ill patients with septic shock, compared to healthy subjects as controls. Additionally, the study examined the association of IL-6 with morbidity and mortality in these patients, as well as its relationship with biomarkers such as lactic acid, C-reactive protein (CRP) and procalcitonin (PCT). <b>Methods:</b> This was a prospective analytical study involving 28 critically ill patients with septic shock, monitored from ICU admission through to their first three days of stay. Demographic data, comorbidities and clinical information, including IL-6 and severity scores, were recorded. <b>Results:</b> IL-6 levels were significantly higher in patients with septic shock compared to healthy subjects (<i>p</i> < 0.001) upon admission. IL-6 levels decreased by the third day of ICU stay (<i>p</i> < 0.005). An association between IL-6 and mortality was observed (areas under the curve 0.826, confidence interval (CI) 95% 0.659−0.994, <i>p</i> < 0.008). Significant correlations between IL-6 and lactic acid (<i>p</i> < 0.009 and <i>p</i> < 0.018) and partial thromboplastin time (<i>p</i> < 0.004 and <i>p</i> < 0.007) were found on the first and third days, respectively. IL-6 was also the correlated with an anion gap at admission to the ICU (<i>p</i> < 0.009). <b>Conclusions:</b> In conclusion, this study suggests that IL-6 could be a valuable marker for early sepsis follow-up in ICU patients, particularly during the first 72 h of hospitalization, providing important prognostic information in patients with septic shock.https://www.mdpi.com/2079-9721/12/11/298interleukin-6inflammationseptic shockmortalitycritical care patient |
| spellingShingle | Yenifer Gamarra-Morales Jorge Molina-López Felipe-Carlos Santiago-Ruiz Lourdes Herrera-Quintana Héctor Vázquez-Lorente Félix Gascón-Luna Elena Planells Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock Diseases interleukin-6 inflammation septic shock mortality critical care patient |
| title | Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock |
| title_full | Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock |
| title_fullStr | Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock |
| title_full_unstemmed | Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock |
| title_short | Efficiency of IL-6 in Early Prognosis and Follow-Up in Critically Ill Patients with Septic Shock |
| title_sort | efficiency of il 6 in early prognosis and follow up in critically ill patients with septic shock |
| topic | interleukin-6 inflammation septic shock mortality critical care patient |
| url | https://www.mdpi.com/2079-9721/12/11/298 |
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