De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis
Background/objectives: According to the Chapel Hill Consensus Conference nomenclature, single-organ cutaneous small vessel vasculitis (SOCV) is defined histopathologically by immune complex-mediated vasculitis of the dermal capillaries/venules without systemic involvement. There is a lack of investi...
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MDPI AG
2025-05-01
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| author | Thilo Gambichler Larisa Ardabili Belanna Domin Laura Susok Nessr Abu Rached |
| author_facet | Thilo Gambichler Larisa Ardabili Belanna Domin Laura Susok Nessr Abu Rached |
| author_sort | Thilo Gambichler |
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| description | Background/objectives: According to the Chapel Hill Consensus Conference nomenclature, single-organ cutaneous small vessel vasculitis (SOCV) is defined histopathologically by immune complex-mediated vasculitis of the dermal capillaries/venules without systemic involvement. There is a lack of investigations studying predictors of SOCV outcomes. This multicenter retrospective study aimed to assess whether baseline serum liver scores could predict SOCV recurrence. Methods: Data from 204 inpatients with histopathologically confirmed idiopathic SOCV treated between 2000 and 2022 were analyzed. All patients had baseline blood tests for platelets and liver parameters; those with systemic diseases were excluded. The study evaluated the AST to Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) index, and De Ritis ratio (DRR). Results: Recurrence was observed in 17.6% of patients. Univariable analysis identified hospital stay length, DRR, cutaneous extent, and cardiovascular comorbidities as predictors, but logistic regression confirmed only cutaneous extent and DRR as independent predictors of disease recurrence. Conclusions: A higher DRR (cut-off > 1.13) may indicate necrosis from reduced blood flow, making it a potential predictor of SOCV recurrence. |
| format | Article |
| id | doaj-art-e0c125daf52540ceba929f5d03398b49 |
| institution | Kabale University |
| issn | 2673-6179 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Dermato |
| spelling | doaj-art-e0c125daf52540ceba929f5d03398b492025-08-20T03:26:56ZengMDPI AGDermato2673-61792025-05-0152810.3390/dermato5020008De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel VasculitisThilo Gambichler0Larisa Ardabili1Belanna Domin2Laura Susok3Nessr Abu Rached4Department of Dermatology, Dortmund Hospital gGmbH, University of Witten/Herdecke, 58455 Witten, GermanyDepartment of Dermatology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Dermatology, Ruhr-University Bochum, 44801 Bochum, GermanyDepartment of Dermatology, Dortmund Hospital gGmbH, University of Witten/Herdecke, 58455 Witten, GermanyDepartment of Dermatology, Ruhr-University Bochum, 44801 Bochum, GermanyBackground/objectives: According to the Chapel Hill Consensus Conference nomenclature, single-organ cutaneous small vessel vasculitis (SOCV) is defined histopathologically by immune complex-mediated vasculitis of the dermal capillaries/venules without systemic involvement. There is a lack of investigations studying predictors of SOCV outcomes. This multicenter retrospective study aimed to assess whether baseline serum liver scores could predict SOCV recurrence. Methods: Data from 204 inpatients with histopathologically confirmed idiopathic SOCV treated between 2000 and 2022 were analyzed. All patients had baseline blood tests for platelets and liver parameters; those with systemic diseases were excluded. The study evaluated the AST to Platelet Ratio Index (APRI), Fibrosis-4 (FIB-4) index, and De Ritis ratio (DRR). Results: Recurrence was observed in 17.6% of patients. Univariable analysis identified hospital stay length, DRR, cutaneous extent, and cardiovascular comorbidities as predictors, but logistic regression confirmed only cutaneous extent and DRR as independent predictors of disease recurrence. Conclusions: A higher DRR (cut-off > 1.13) may indicate necrosis from reduced blood flow, making it a potential predictor of SOCV recurrence.https://www.mdpi.com/2673-6179/5/2/8leukocytoclastic vasculitishypersensitivity angiitisbiomarkersrelapse |
| spellingShingle | Thilo Gambichler Larisa Ardabili Belanna Domin Laura Susok Nessr Abu Rached De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis Dermato leukocytoclastic vasculitis hypersensitivity angiitis biomarkers relapse |
| title | De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis |
| title_full | De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis |
| title_fullStr | De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis |
| title_full_unstemmed | De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis |
| title_short | De Ritis Ratio Is a Potential Independent Predictor of Recurrence of Single-Organ Cutaneous Small Vessel Vasculitis |
| title_sort | de ritis ratio is a potential independent predictor of recurrence of single organ cutaneous small vessel vasculitis |
| topic | leukocytoclastic vasculitis hypersensitivity angiitis biomarkers relapse |
| url | https://www.mdpi.com/2673-6179/5/2/8 |
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