Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023)
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2025-02-01
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| Series: | Zoonoses |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0060 |
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| _version_ | 1849319972454531072 |
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| author | Shulei Jia Xuebin Xu Mengqi Qu Yuhang Pei Siqi Sun Yue Liu Wanting Dong Yongfei Hu Baoli Zhu George F. Gao Yanan Wang |
| author_facet | Shulei Jia Xuebin Xu Mengqi Qu Yuhang Pei Siqi Sun Yue Liu Wanting Dong Yongfei Hu Baoli Zhu George F. Gao Yanan Wang |
| author_sort | Shulei Jia |
| collection | DOAJ |
| description | <div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d1447918e254">
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<h5 class="section-title" id="d1447918e255">Objective:</h5>
<p dir="auto" id="d1447918e257">The zoonotic pathogen
<i>Campylobacter</i> is a major foodborne bacterial species worldwide. The distribution and drivers of
antimicrobial resistance (AMR) in global
<i>Campylobacter</i> strains remain largely unknown. Therefore, a comprehensive analysis of longitudinal
trends and driving factors of AMR in
<i>Campylobacter</i> is necessary at a global level.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d1447918e268">
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<h5 class="section-title" id="d1447918e269">Methods:</h5>
<p dir="auto" id="d1447918e271">We downloaded from public repositories 66,771
<i>Campylobacter</i> genomes (24,115 from
<i>C. coli</i> and 42,656 from
<i>C. jejuni</i>) in 53 countries/regions during 1954–2023, and performed a comprehensive analysis.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d1447918e282">
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named anchor
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</a>
<h5 class="section-title" id="d1447918e283">Results:</h5>
<p dir="auto" id="d1447918e285">We categorized the
<i>Campylobacter</i> isolates into 2,771 sequence types (STs), 45 of which were shared among humans, chickens,
pigs, cattle, and the environment. We uncovered the spatial and temporal characteristics
of resistance across antimicrobial classes on a global scale, and observed increased
trends in the aminoglycoside, tetracycline, and fluoroquinolone resistance of
<i>C. jejuni</i> during the past 23 years. Some of the antibiotic, climate, and socioeconomic indicators
collected from the World Bank might potentially have driven the rise of AMR in various
countries/regions to varying degrees.
</p>
</div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section">
<a class="named-anchor" id="d1447918e293">
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named anchor
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</a>
<h5 class="section-title" id="d1447918e294">Conclusions:</h5>
<p dir="auto" id="d1447918e296">In summary, we present a global genetic atlas of
<i>Campylobacter</i>, which provides valuable insights for understanding the transmission dynamics of
AMR in this species.
</p>
</div> |
| format | Article |
| id | doaj-art-e0bee0dc7ad94323b48d5e747606436b |
| institution | Kabale University |
| issn | 2737-7466 2737-7474 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Zoonoses |
| spelling | doaj-art-e0bee0dc7ad94323b48d5e747606436b2025-08-20T03:50:16ZengCompuscript LtdZoonoses2737-74662737-74742025-02-015198910.15212/ZOONOSES-2024-0060Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023)Shulei JiaXuebin XuMengqi QuYuhang PeiSiqi SunYue LiuWanting DongYongfei HuBaoli ZhuGeorge F. GaoYanan Wang<div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d1447918e254"> <!-- named anchor --> </a> <h5 class="section-title" id="d1447918e255">Objective:</h5> <p dir="auto" id="d1447918e257">The zoonotic pathogen <i>Campylobacter</i> is a major foodborne bacterial species worldwide. The distribution and drivers of antimicrobial resistance (AMR) in global <i>Campylobacter</i> strains remain largely unknown. Therefore, a comprehensive analysis of longitudinal trends and driving factors of AMR in <i>Campylobacter</i> is necessary at a global level. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d1447918e268"> <!-- named anchor --> </a> <h5 class="section-title" id="d1447918e269">Methods:</h5> <p dir="auto" id="d1447918e271">We downloaded from public repositories 66,771 <i>Campylobacter</i> genomes (24,115 from <i>C. coli</i> and 42,656 from <i>C. jejuni</i>) in 53 countries/regions during 1954–2023, and performed a comprehensive analysis. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d1447918e282"> <!-- named anchor --> </a> <h5 class="section-title" id="d1447918e283">Results:</h5> <p dir="auto" id="d1447918e285">We categorized the <i>Campylobacter</i> isolates into 2,771 sequence types (STs), 45 of which were shared among humans, chickens, pigs, cattle, and the environment. We uncovered the spatial and temporal characteristics of resistance across antimicrobial classes on a global scale, and observed increased trends in the aminoglycoside, tetracycline, and fluoroquinolone resistance of <i>C. jejuni</i> during the past 23 years. Some of the antibiotic, climate, and socioeconomic indicators collected from the World Bank might potentially have driven the rise of AMR in various countries/regions to varying degrees. </p> </div><div xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="section"> <a class="named-anchor" id="d1447918e293"> <!-- named anchor --> </a> <h5 class="section-title" id="d1447918e294">Conclusions:</h5> <p dir="auto" id="d1447918e296">In summary, we present a global genetic atlas of <i>Campylobacter</i>, which provides valuable insights for understanding the transmission dynamics of AMR in this species. </p> </div>https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0060 |
| spellingShingle | Shulei Jia Xuebin Xu Mengqi Qu Yuhang Pei Siqi Sun Yue Liu Wanting Dong Yongfei Hu Baoli Zhu George F. Gao Yanan Wang Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) Zoonoses |
| title | Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) |
| title_full | Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) |
| title_fullStr | Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) |
| title_full_unstemmed | Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) |
| title_short | Longitudinal Trends and Drivers of Antimicrobial Resistance in <i>Campylobacter</i> Worldwide (1954-2023) |
| title_sort | longitudinal trends and drivers of antimicrobial resistance in i campylobacter i worldwide 1954 2023 |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0060 |
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