Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies
Introduction Schizophrenia is a chronic, complex and severe psychiatric disorder affecting millions of people every year and inflicting different costs to the individual, family and community. A growing body of evidence has introduced several genetic and environmental factors and their interactions...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/8/e068626.full |
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| author | Seyyed Muhammad Mahdi Mahdavinoor Aghil Mollaei Sara Farhang |
| author_facet | Seyyed Muhammad Mahdi Mahdavinoor Aghil Mollaei Sara Farhang |
| author_sort | Seyyed Muhammad Mahdi Mahdavinoor |
| collection | DOAJ |
| description | Introduction Schizophrenia is a chronic, complex and severe psychiatric disorder affecting millions of people every year and inflicting different costs to the individual, family and community. A growing body of evidence has introduced several genetic and environmental factors and their interactions as aetiological factors of schizophrenia. The goal of this systematic review and meta-analysis is to present an updated representation of the global environmental risk factors of schizophrenia.Method and analysis This protocol is developed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guideline. We will systematically search the databases such as PubMed, Scopus, Web of Science, PsycINFO and Embase until 30 September 2022. We include Cohort studies that have reported one or more risk factors of schizophrenia. We will also search Google Scholar search engine and references lists of included articles. Extracting the relevant data and assessing the quality of the included studies will be independently performed by different authors of our team. The risk of bias for the included studies will be evaluated using Newcastle-Ottawa Scale. Subgroup analysis, meta-regression or sensitivity analysis will be our solution to deal with heterogeneity between studies. We will use a funnel diagram as well as Begg and Egger tests to check for possible publication bias.Ethics and dissemination Ethical approval is not required because there will be no primary data collection or human involvement. The results of this study will be published in an international peer-reviewed journal.PROSPERO registration number CRD42022359327. |
| format | Article |
| id | doaj-art-e0bb39330e7349c593a677723c01faaa |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e0bb39330e7349c593a677723c01faaa2025-08-20T02:14:59ZengBMJ Publishing GroupBMJ Open2044-60552023-08-0113810.1136/bmjopen-2022-068626Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studiesSeyyed Muhammad Mahdi Mahdavinoor0Aghil Mollaei1Sara Farhang2Student Research Committee, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran (the Islamic Republic of)Student Research Committee, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran (the Islamic Republic of)University of Groningen, University medical center Groningen, University Center for Psychiatry, Rob Giel research center, Groningen, The NetherlandsIntroduction Schizophrenia is a chronic, complex and severe psychiatric disorder affecting millions of people every year and inflicting different costs to the individual, family and community. A growing body of evidence has introduced several genetic and environmental factors and their interactions as aetiological factors of schizophrenia. The goal of this systematic review and meta-analysis is to present an updated representation of the global environmental risk factors of schizophrenia.Method and analysis This protocol is developed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guideline. We will systematically search the databases such as PubMed, Scopus, Web of Science, PsycINFO and Embase until 30 September 2022. We include Cohort studies that have reported one or more risk factors of schizophrenia. We will also search Google Scholar search engine and references lists of included articles. Extracting the relevant data and assessing the quality of the included studies will be independently performed by different authors of our team. The risk of bias for the included studies will be evaluated using Newcastle-Ottawa Scale. Subgroup analysis, meta-regression or sensitivity analysis will be our solution to deal with heterogeneity between studies. We will use a funnel diagram as well as Begg and Egger tests to check for possible publication bias.Ethics and dissemination Ethical approval is not required because there will be no primary data collection or human involvement. The results of this study will be published in an international peer-reviewed journal.PROSPERO registration number CRD42022359327.https://bmjopen.bmj.com/content/13/8/e068626.full |
| spellingShingle | Seyyed Muhammad Mahdi Mahdavinoor Aghil Mollaei Sara Farhang Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies BMJ Open |
| title | Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies |
| title_full | Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies |
| title_fullStr | Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies |
| title_full_unstemmed | Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies |
| title_short | Global environmental risk factors of schizophrenia: a study protocol for systematic review and meta-analysis of cohort studies |
| title_sort | global environmental risk factors of schizophrenia a study protocol for systematic review and meta analysis of cohort studies |
| url | https://bmjopen.bmj.com/content/13/8/e068626.full |
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