Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review

Intrathecal chemotherapy is routinely prescribed in medical oncology practice, either for prophylaxis or for treatment of leptomeningeal disease due to a primary haematological disease or a metastatic disease due to any other malignancy. As these groups of patients are coagulopathic either because o...

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Main Author: Abhijit Nair
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.1155/2016/3759845
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author Abhijit Nair
author_facet Abhijit Nair
author_sort Abhijit Nair
collection DOAJ
description Intrathecal chemotherapy is routinely prescribed in medical oncology practice, either for prophylaxis or for treatment of leptomeningeal disease due to a primary haematological disease or a metastatic disease due to any other malignancy. As these groups of patients are coagulopathic either because of the disease per se or due to systemic chemotherapy, lumbar puncture in them is considered challenging and is expected to be performed by an anaesthesiologist because of their expertise in this procedure. However, the challenge is not only in performing the lumbar puncture safely but also in dealing with other issues like explaining and handling complications that can happen either due to the drug injected intrathecally or due to a neurodeficit occurring either due to the underlying coagulopathy or due to the progression of leptomeningeal disease.
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spelling doaj-art-e0ba2855cced4857b1acdf3e5750e9f12025-02-03T05:50:25ZengWileyScientifica2090-908X2016-01-01201610.1155/2016/37598453759845Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief ReviewAbhijit Nair0Department of Anaesthesiology, Basavatarakam Indo-American Cancer Institute and Research Centre, Hyderabad 500034, IndiaIntrathecal chemotherapy is routinely prescribed in medical oncology practice, either for prophylaxis or for treatment of leptomeningeal disease due to a primary haematological disease or a metastatic disease due to any other malignancy. As these groups of patients are coagulopathic either because of the disease per se or due to systemic chemotherapy, lumbar puncture in them is considered challenging and is expected to be performed by an anaesthesiologist because of their expertise in this procedure. However, the challenge is not only in performing the lumbar puncture safely but also in dealing with other issues like explaining and handling complications that can happen either due to the drug injected intrathecally or due to a neurodeficit occurring either due to the underlying coagulopathy or due to the progression of leptomeningeal disease.http://dx.doi.org/10.1155/2016/3759845
spellingShingle Abhijit Nair
Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
Scientifica
title Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
title_full Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
title_fullStr Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
title_full_unstemmed Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
title_short Implications of Intrathecal Chemotherapy for Anaesthesiologists: A Brief Review
title_sort implications of intrathecal chemotherapy for anaesthesiologists a brief review
url http://dx.doi.org/10.1155/2016/3759845
work_keys_str_mv AT abhijitnair implicationsofintrathecalchemotherapyforanaesthesiologistsabriefreview