Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
ABSTRACT Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer. Previously, due to technical issues and low biological content, little was known about the microbial community within tumors. Wi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Exploration |
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| Online Access: | https://doi.org/10.1002/EXP.20210185 |
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| author | Yanan Niu Junya Feng Jie Ma Tixian Xiao Wei Yuan |
| author_facet | Yanan Niu Junya Feng Jie Ma Tixian Xiao Wei Yuan |
| author_sort | Yanan Niu |
| collection | DOAJ |
| description | ABSTRACT Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer. Previously, due to technical issues and low biological content, little was known about the microbial community within tumors. With the development of high‐throughput sequencing technology and molecular biology techniques, it has been demonstrated that tumors harbor highly heterogeneous symbiotic microbial communities, which affect tumor progression mechanisms through various pathways, such as inducing DNA damage, activating carcinogenic pathways, and inducing an immunesuppressive environment. Faced with the harmful microbial communities in the TME, efforts have been made to develop new technologies specifically targeting the microbiome and tumor microecology. Given the success of nanotechnology in cancer diagnosis and treatment, the development of nanotechnology to regulate microscale and molecular‐scale interactions occurring in the microbiome and tumor microecology holds promise for providing new approaches for cancer therapy. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral microorganisms using nanotechnology. Additionally, this article delivers prospects for the potential clinical significance and challenges of anti‐tumor strategies against intra‐tumoral microorganisms. |
| format | Article |
| id | doaj-art-e0b99832d07743e788b232a232a4bb6d |
| institution | Kabale University |
| issn | 2766-8509 2766-2098 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Exploration |
| spelling | doaj-art-e0b99832d07743e788b232a232a4bb6d2025-08-26T10:33:03ZengWileyExploration2766-85092766-20982025-08-0154n/an/a10.1002/EXP.20210185Targeting the Tumor Microbiota in Cancer Therapy Basing on NanomaterialsYanan Niu0Junya Feng1Jie Ma2Tixian Xiao3Wei Yuan4State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing P. R. ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing P. R. ChinaDepartment of Biotherapy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences Graduate School of Peking Union Medical College Beijing P. R. ChinaDepartment of Colorectal Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing P. R. ChinaState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences Peking Union Medical College Beijing P. R. ChinaABSTRACT Intra‐tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer. Previously, due to technical issues and low biological content, little was known about the microbial community within tumors. With the development of high‐throughput sequencing technology and molecular biology techniques, it has been demonstrated that tumors harbor highly heterogeneous symbiotic microbial communities, which affect tumor progression mechanisms through various pathways, such as inducing DNA damage, activating carcinogenic pathways, and inducing an immunesuppressive environment. Faced with the harmful microbial communities in the TME, efforts have been made to develop new technologies specifically targeting the microbiome and tumor microecology. Given the success of nanotechnology in cancer diagnosis and treatment, the development of nanotechnology to regulate microscale and molecular‐scale interactions occurring in the microbiome and tumor microecology holds promise for providing new approaches for cancer therapy. This article reviews the latest progress in this field, including the microbial community within tumors and its pro‐cancer mechanisms, as well as the anti‐tumor strategies targeting intra‐tumoral microorganisms using nanotechnology. Additionally, this article delivers prospects for the potential clinical significance and challenges of anti‐tumor strategies against intra‐tumoral microorganisms.https://doi.org/10.1002/EXP.20210185antibacterialintra‐tumoral microbiotananomaterialstumor therapy |
| spellingShingle | Yanan Niu Junya Feng Jie Ma Tixian Xiao Wei Yuan Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials Exploration antibacterial intra‐tumoral microbiota nanomaterials tumor therapy |
| title | Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials |
| title_full | Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials |
| title_fullStr | Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials |
| title_full_unstemmed | Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials |
| title_short | Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials |
| title_sort | targeting the tumor microbiota in cancer therapy basing on nanomaterials |
| topic | antibacterial intra‐tumoral microbiota nanomaterials tumor therapy |
| url | https://doi.org/10.1002/EXP.20210185 |
| work_keys_str_mv | AT yananniu targetingthetumormicrobiotaincancertherapybasingonnanomaterials AT junyafeng targetingthetumormicrobiotaincancertherapybasingonnanomaterials AT jiema targetingthetumormicrobiotaincancertherapybasingonnanomaterials AT tixianxiao targetingthetumormicrobiotaincancertherapybasingonnanomaterials AT weiyuan targetingthetumormicrobiotaincancertherapybasingonnanomaterials |