Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia
Background: Early onset preeclampsia (PE) is considered a fetal disorder that is associated with placental dysfunction. While late onset preeclampsia is considered a maternal disorder that associated with a normal placenta. An imbalance of angiogenesis factors, namely soluble Fms-like tyrosine kinas...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cell and BioPharmaceutical Institute
2024-11-01
|
| Series: | MCBS (Molecular and Cellular Biomedical Sciences) |
| Online Access: | https://cellbiopharm.com/ojs/index.php/MCBS/article/view/465 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850285021260152832 |
|---|---|
| author | Joserizal Serudji vaulinne Basyir Tara Fadhillah |
| author_facet | Joserizal Serudji vaulinne Basyir Tara Fadhillah |
| author_sort | Joserizal Serudji |
| collection | DOAJ |
| description | Background: Early onset preeclampsia (PE) is considered a fetal disorder that is associated with placental dysfunction. While late onset preeclampsia is considered a maternal disorder that associated with a normal placenta. An imbalance of angiogenesis factors, namely soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) is not only a strong predictor of PE but can also be a predictor of poor outcomes or adverse complications of PE. This study was conducted to analyze the difference between angiogenesis factor sFlt-1 and PlGF in maternal serum between patients with early and late onset PE.
Material and Methods: This was a cross-sectional study involving pregnant women with PE who were ≥18 years old and gestational age >20 weeks had singleton pregnancies. Subjects who had a major morphological abnormality of a fetus diagnosed with USG and chromosomal abnormality of the fetus were be excluded. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured using a digital blood pressure measuring instrument. sFlt-1 and PlGF levels were measured using enzyme linked immunosorbent assay (ELISA).
Result: This study showed the level of maternal serum sFlt-1 was 7522.95 pg/mL and the level of maternal serum PlGF was 222.25 pg/mL. There was a difference between sflt-1, PlGF, and the sflt-1/PlGF ratio (p=0.00; p=0.00; p=0.00) in early and late onset of PE where at early onset PE was found higher sflt-1 and late-onset PE had lower PlGF and higher sflt-1/PlGF ratio.
Conclusion: There are differences in sFlt-1, PlGF, and sFlt-1/PlGF in early and late onset PE, as higher sflt-1 is found in early onset preeclampsia, while lower PlGF and higher sflt-1/PlGF ratio are found in late onset preeclampsia.
Keywords: early onset, late onset, preeclampsia, maternal angiogenesis factor, Flt-1, PlGF |
| format | Article |
| id | doaj-art-e0b8321f64ff409da9021cb2fc1195a2 |
| institution | OA Journals |
| issn | 2527-4384 2527-3442 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Cell and BioPharmaceutical Institute |
| record_format | Article |
| series | MCBS (Molecular and Cellular Biomedical Sciences) |
| spelling | doaj-art-e0b8321f64ff409da9021cb2fc1195a22025-08-20T01:47:25ZengCell and BioPharmaceutical InstituteMCBS (Molecular and Cellular Biomedical Sciences)2527-43842527-34422024-11-01831545810.21705/mcbs.v8i3.465142Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset PreeclampsiaJoserizal Serudji0vaulinne Basyir1Tara Fadhillah2Fetomaternal Division, Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Andalas, PadangFetomaternal Division, Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Andalas, PadangObstetrics and Gynecology Department, Faculty of Medicine, Universitas Andalas, PadangBackground: Early onset preeclampsia (PE) is considered a fetal disorder that is associated with placental dysfunction. While late onset preeclampsia is considered a maternal disorder that associated with a normal placenta. An imbalance of angiogenesis factors, namely soluble Fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) is not only a strong predictor of PE but can also be a predictor of poor outcomes or adverse complications of PE. This study was conducted to analyze the difference between angiogenesis factor sFlt-1 and PlGF in maternal serum between patients with early and late onset PE. Material and Methods: This was a cross-sectional study involving pregnant women with PE who were ≥18 years old and gestational age >20 weeks had singleton pregnancies. Subjects who had a major morphological abnormality of a fetus diagnosed with USG and chromosomal abnormality of the fetus were be excluded. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were measured using a digital blood pressure measuring instrument. sFlt-1 and PlGF levels were measured using enzyme linked immunosorbent assay (ELISA). Result: This study showed the level of maternal serum sFlt-1 was 7522.95 pg/mL and the level of maternal serum PlGF was 222.25 pg/mL. There was a difference between sflt-1, PlGF, and the sflt-1/PlGF ratio (p=0.00; p=0.00; p=0.00) in early and late onset of PE where at early onset PE was found higher sflt-1 and late-onset PE had lower PlGF and higher sflt-1/PlGF ratio. Conclusion: There are differences in sFlt-1, PlGF, and sFlt-1/PlGF in early and late onset PE, as higher sflt-1 is found in early onset preeclampsia, while lower PlGF and higher sflt-1/PlGF ratio are found in late onset preeclampsia. Keywords: early onset, late onset, preeclampsia, maternal angiogenesis factor, Flt-1, PlGFhttps://cellbiopharm.com/ojs/index.php/MCBS/article/view/465 |
| spellingShingle | Joserizal Serudji vaulinne Basyir Tara Fadhillah Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia MCBS (Molecular and Cellular Biomedical Sciences) |
| title | Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia |
| title_full | Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia |
| title_fullStr | Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia |
| title_full_unstemmed | Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia |
| title_short | Differentiating Maternal Angiogenesis Factors between Early and Late Onset Preeclampsia: Higher sflt-1 in Early Onset Preeclampsia, Lower PlGF and Higher sflt-1/PlGF Ratio in Late Onset Preeclampsia |
| title_sort | differentiating maternal angiogenesis factors between early and late onset preeclampsia higher sflt 1 in early onset preeclampsia lower plgf and higher sflt 1 plgf ratio in late onset preeclampsia |
| url | https://cellbiopharm.com/ojs/index.php/MCBS/article/view/465 |
| work_keys_str_mv | AT joserizalserudji differentiatingmaternalangiogenesisfactorsbetweenearlyandlateonsetpreeclampsiahighersflt1inearlyonsetpreeclampsialowerplgfandhighersflt1plgfratioinlateonsetpreeclampsia AT vaulinnebasyir differentiatingmaternalangiogenesisfactorsbetweenearlyandlateonsetpreeclampsiahighersflt1inearlyonsetpreeclampsialowerplgfandhighersflt1plgfratioinlateonsetpreeclampsia AT tarafadhillah differentiatingmaternalangiogenesisfactorsbetweenearlyandlateonsetpreeclampsiahighersflt1inearlyonsetpreeclampsialowerplgfandhighersflt1plgfratioinlateonsetpreeclampsia |