Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction
Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are critical in regulating tissue fluid homeostasis an...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557250/full |
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| author | Zhihua Yang Zhihua Yang Zeyu Zhang Zeyu Zhang Shaoling Feng Shaoling Feng Xujin Ning Xujin Ning Liuli Guo Yijia Du Yijia Du Shuai Wang Shuai Wang Xianliang Wang Xianliang Wang Jingyuan Mao Jingyuan Mao |
| author_facet | Zhihua Yang Zhihua Yang Zeyu Zhang Zeyu Zhang Shaoling Feng Shaoling Feng Xujin Ning Xujin Ning Liuli Guo Yijia Du Yijia Du Shuai Wang Shuai Wang Xianliang Wang Xianliang Wang Jingyuan Mao Jingyuan Mao |
| author_sort | Zhihua Yang |
| collection | DOAJ |
| description | Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are critical in regulating tissue fluid homeostasis and systemic immune surveillance. Cardiac lymphatics interact with immune cells, directly and indirectly, to mediate post-MI inflammation, participate in the clearance of necrotic tissue, and contribute to cardiac remodeling. Studies indicate that after MI, promoting cardiac lymphangiogenesis can accelerate the clearance of infiltrated immune cells, reduce the production of pro-inflammatory cytokines, improve myocardial edema, mitigate inflammatory responses and fibrosis, and support recovery of cardiac function. Meanwhile, immune cells regulate the structure and function of cardiac lymphatics, influencing lymphangiogenesis and drainage efficiency. The interaction between cardiac lymphatics and immune cells is crucial for myocardial repair post-MI. This review first systematically summarizes the structure and function of cardiac lymphatics, then sorting the relationship between cardiac lymphatics and immune cells and their roles in myocardial repair after MI and finally proposes therapeutic strategies targeting the interaction between cardiac lymphatics and immune cells in MI treatment, to provide prospective insights for the prevention and treatment of MI in the future. |
| format | Article |
| id | doaj-art-e0b61f5de63e4fbd9dde228ca6303a94 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e0b61f5de63e4fbd9dde228ca6303a942025-08-20T02:32:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15572501557250Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarctionZhihua Yang0Zhihua Yang1Zeyu Zhang2Zeyu Zhang3Shaoling Feng4Shaoling Feng5Xujin Ning6Xujin Ning7Liuli Guo8Yijia Du9Yijia Du10Shuai Wang11Shuai Wang12Xianliang Wang13Xianliang Wang14Jingyuan Mao15Jingyuan Mao16Department of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaDepartment of Cardiovascular Diseases, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaMyocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are critical in regulating tissue fluid homeostasis and systemic immune surveillance. Cardiac lymphatics interact with immune cells, directly and indirectly, to mediate post-MI inflammation, participate in the clearance of necrotic tissue, and contribute to cardiac remodeling. Studies indicate that after MI, promoting cardiac lymphangiogenesis can accelerate the clearance of infiltrated immune cells, reduce the production of pro-inflammatory cytokines, improve myocardial edema, mitigate inflammatory responses and fibrosis, and support recovery of cardiac function. Meanwhile, immune cells regulate the structure and function of cardiac lymphatics, influencing lymphangiogenesis and drainage efficiency. The interaction between cardiac lymphatics and immune cells is crucial for myocardial repair post-MI. This review first systematically summarizes the structure and function of cardiac lymphatics, then sorting the relationship between cardiac lymphatics and immune cells and their roles in myocardial repair after MI and finally proposes therapeutic strategies targeting the interaction between cardiac lymphatics and immune cells in MI treatment, to provide prospective insights for the prevention and treatment of MI in the future.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557250/fullcardiac lymphaticsimmune cellmyocardial infarctioncardiac recoverylymphangiogenesismyocardial fibrosis |
| spellingShingle | Zhihua Yang Zhihua Yang Zeyu Zhang Zeyu Zhang Shaoling Feng Shaoling Feng Xujin Ning Xujin Ning Liuli Guo Yijia Du Yijia Du Shuai Wang Shuai Wang Xianliang Wang Xianliang Wang Jingyuan Mao Jingyuan Mao Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction Frontiers in Immunology cardiac lymphatics immune cell myocardial infarction cardiac recovery lymphangiogenesis myocardial fibrosis |
| title | Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| title_full | Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| title_fullStr | Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| title_full_unstemmed | Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| title_short | Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| title_sort | cross talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction |
| topic | cardiac lymphatics immune cell myocardial infarction cardiac recovery lymphangiogenesis myocardial fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557250/full |
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