Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male
Osteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity. Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis. Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis mo...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/182753 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566718214438912 |
|---|---|
| author | Silvia Migliaccio Davide Francomano Roberto Bruzziches Emanuela A. Greco Rachele Fornari Lorenzo M. Donini Andrea Lenzi Antonio Aversa |
| author_facet | Silvia Migliaccio Davide Francomano Roberto Bruzziches Emanuela A. Greco Rachele Fornari Lorenzo M. Donini Andrea Lenzi Antonio Aversa |
| author_sort | Silvia Migliaccio |
| collection | DOAJ |
| description | Osteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity. Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis. Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old). Independently from BMI, an inverse relationship between trunk fat percentage and plasma T (r2=−0.26, P<0.01) and between HOMA-IR and OSCA levels (r2=−0.22, P<0.005) was found. OSCA levels, as well as vitamin D, decreased significantly for higher BMI with significant differences above 35 (P<0.01). A direct correlation between T and bone mineral density at lumbar (BMDL) and neck (BMDH) (P<0.001, r2=−0.20; P<0.001, r2=−0.24) was found, independently from age. An inverse correlation between E2 levels, BMDL, and BMDH (P<0.001, r2=−0.20; P<0.001, r2=−0.19) was observed. These data provide new evidences that a relationship between trunk fat mass, insulin sensitivity, OSCA and T synthesis occurs. This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status. |
| format | Article |
| id | doaj-art-e0b4cbc932ce4420a0894838bacbd9b8 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e0b4cbc932ce4420a0894838bacbd9b82025-02-03T01:03:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/182753182753Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging MaleSilvia Migliaccio0Davide Francomano1Roberto Bruzziches2Emanuela A. Greco3Rachele Fornari4Lorenzo M. Donini5Andrea Lenzi6Antonio Aversa7Department of Movement, Human and Health Sciences, Unit of Endocrinology, University of Rome “Foro Italico”, Largo Lauro De Bosis 15, 00195 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyDepartment of Experimental Medicine, Medical Pathophysiology, Food and Science and Endocrinology Section, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, ItalyOsteocalcin (OSCA) seems to act as a negative regulator of energy metabolism and insulin sensitivity. Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis. Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old). Independently from BMI, an inverse relationship between trunk fat percentage and plasma T (r2=−0.26, P<0.01) and between HOMA-IR and OSCA levels (r2=−0.22, P<0.005) was found. OSCA levels, as well as vitamin D, decreased significantly for higher BMI with significant differences above 35 (P<0.01). A direct correlation between T and bone mineral density at lumbar (BMDL) and neck (BMDH) (P<0.001, r2=−0.20; P<0.001, r2=−0.24) was found, independently from age. An inverse correlation between E2 levels, BMDL, and BMDH (P<0.001, r2=−0.20; P<0.001, r2=−0.19) was observed. These data provide new evidences that a relationship between trunk fat mass, insulin sensitivity, OSCA and T synthesis occurs. This new relationship with skeletal health has relevant implications for the aging male, suggesting OSCA as a novel marker of metabolic and gonadal health status.http://dx.doi.org/10.1155/2013/182753 |
| spellingShingle | Silvia Migliaccio Davide Francomano Roberto Bruzziches Emanuela A. Greco Rachele Fornari Lorenzo M. Donini Andrea Lenzi Antonio Aversa Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male International Journal of Endocrinology |
| title | Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male |
| title_full | Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male |
| title_fullStr | Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male |
| title_full_unstemmed | Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male |
| title_short | Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male |
| title_sort | trunk fat negatively influences skeletal and testicular functions in obese men clinical implications for the aging male |
| url | http://dx.doi.org/10.1155/2013/182753 |
| work_keys_str_mv | AT silviamigliaccio trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT davidefrancomano trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT robertobruzziches trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT emanuelaagreco trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT rachelefornari trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT lorenzomdonini trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT andrealenzi trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale AT antonioaversa trunkfatnegativelyinfluencesskeletalandtesticularfunctionsinobesemenclinicalimplicationsfortheagingmale |