In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system

Abstract The OP9 culture system is an important in vitro model for B cell development. However, the complex nature of operations and the intrinsic variability of stromal cell functionality, which can be influenced by factors such as radiation exposure or contamination, pose considerable challenges t...

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Main Authors: Pan Yang, Xiaoling Chen, Hao Wen, Meiling Yu, Haili Yu, Li Wang, Liang Gong, Lintao Zhao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Immunology
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Online Access:https://doi.org/10.1186/s12865-025-00694-8
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author Pan Yang
Xiaoling Chen
Hao Wen
Meiling Yu
Haili Yu
Li Wang
Liang Gong
Lintao Zhao
author_facet Pan Yang
Xiaoling Chen
Hao Wen
Meiling Yu
Haili Yu
Li Wang
Liang Gong
Lintao Zhao
author_sort Pan Yang
collection DOAJ
description Abstract The OP9 culture system is an important in vitro model for B cell development. However, the complex nature of operations and the intrinsic variability of stromal cell functionality, which can be influenced by factors such as radiation exposure or contamination, pose considerable challenges to their wider application. Currently, there exists a paucity of studies documenting in vitro B cell differentiation culture systems that exclude stromal cells, and the experimental methodologies available for reference remain limited. This report elucidates a robust stromal cell-free culture system. Specifically, bovine serum albumin (BSA) or fetal bovine serum (FBS), in conjunction with interleukin-7 (IL-7), Flt3 ligand (Flt3L), and stem cell factor (SCF), were incorporated into X-VIVO15 medium. This system proficiently facilitates the directed differentiation of common lymphoid progenitor cells (CLP), defined as lineage-CD127 + CD117lowsca-1lowCD135+, into B lymphocytes in vitro, achieving an amplification factor of up to one hundredfold. We examined the roles of IL-7, Flt3L and SCF in differentiation of B cells from CLP in this culture system. Our findings indicate that IL-7 is a pivotal cytokine essential for B cell differentiation in vitro, demonstrating a notable synergistic impact when combined with SCF and FLT3L. Moreover, this system is capable of supporting the differentiation of hematopoietic stem cells (HSCs) and lymphoid-primed multipotent progenitor cells (LMPPs) into B cells in vitro. The findings substantiated the efficacy of the culture system in investigating the in vitro differentiation of bone marrow-derived progenitor cells into B cells and elucidated the specific roles of BSA, FBS and three cytokines (IL-7, FLT3L and SCF) in promoting efficient B lineage differentiation.
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spelling doaj-art-e0b055efbf04478d9e86ae80c188d2be2025-08-20T01:57:51ZengBMCBMC Immunology1471-21722025-03-0126111210.1186/s12865-025-00694-8In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture systemPan Yang0Xiaoling Chen1Hao Wen2Meiling Yu3Haili Yu4Li Wang5Liang Gong6Lintao Zhao7Department of Respiratory And Critical Care Medicine, First Affiliated Hospital of Army Medical UniversityInstitute of Immunology PLA, Army Medical UniversityInstitute of Immunology PLA, Army Medical UniversityInstitute of Immunology PLA, Army Medical UniversityBiomedical Analysis Center PLA, Army Medical UniversityInstitute of Immunology PLA, Army Medical UniversityDepartment of Respiratory And Critical Care Medicine, First Affiliated Hospital of Army Medical UniversityDepartment of Respiratory And Critical Care Medicine, First Affiliated Hospital of Army Medical UniversityAbstract The OP9 culture system is an important in vitro model for B cell development. However, the complex nature of operations and the intrinsic variability of stromal cell functionality, which can be influenced by factors such as radiation exposure or contamination, pose considerable challenges to their wider application. Currently, there exists a paucity of studies documenting in vitro B cell differentiation culture systems that exclude stromal cells, and the experimental methodologies available for reference remain limited. This report elucidates a robust stromal cell-free culture system. Specifically, bovine serum albumin (BSA) or fetal bovine serum (FBS), in conjunction with interleukin-7 (IL-7), Flt3 ligand (Flt3L), and stem cell factor (SCF), were incorporated into X-VIVO15 medium. This system proficiently facilitates the directed differentiation of common lymphoid progenitor cells (CLP), defined as lineage-CD127 + CD117lowsca-1lowCD135+, into B lymphocytes in vitro, achieving an amplification factor of up to one hundredfold. We examined the roles of IL-7, Flt3L and SCF in differentiation of B cells from CLP in this culture system. Our findings indicate that IL-7 is a pivotal cytokine essential for B cell differentiation in vitro, demonstrating a notable synergistic impact when combined with SCF and FLT3L. Moreover, this system is capable of supporting the differentiation of hematopoietic stem cells (HSCs) and lymphoid-primed multipotent progenitor cells (LMPPs) into B cells in vitro. The findings substantiated the efficacy of the culture system in investigating the in vitro differentiation of bone marrow-derived progenitor cells into B cells and elucidated the specific roles of BSA, FBS and three cytokines (IL-7, FLT3L and SCF) in promoting efficient B lineage differentiation.https://doi.org/10.1186/s12865-025-00694-8Vitro differentiationCommon lymphoid progenitor cellsB cellstromal cell free culture system
spellingShingle Pan Yang
Xiaoling Chen
Hao Wen
Meiling Yu
Haili Yu
Li Wang
Liang Gong
Lintao Zhao
In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
BMC Immunology
Vitro differentiation
Common lymphoid progenitor cells
B cell
stromal cell free culture system
title In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
title_full In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
title_fullStr In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
title_full_unstemmed In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
title_short In vitro differentiation of common lymphoid progenitor cells into B cell using stromal cell free culture system
title_sort in vitro differentiation of common lymphoid progenitor cells into b cell using stromal cell free culture system
topic Vitro differentiation
Common lymphoid progenitor cells
B cell
stromal cell free culture system
url https://doi.org/10.1186/s12865-025-00694-8
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