Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah
Background. The prevalence of Clostridium difficile infection (CDI) as a common complication among inflammatory bowel disease (IBD) has been reported to increase worldwide and has been associated with a poor IBD outcome. Objectives. In this study, our aim was to report on the prevalence of CDI among...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2023/9958104 |
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| author | Ghassan Abdulrahman Sukkar Syed Sameer Aga Abdulrahman Hamid Alsamadani Faisal Ghazi Almalki Ali Saleh Alsudais Abdulrahman Sulaiman Alquzi Mohamed Eldigire Ahmed Mushtaq Ahmad Mir Moudi M. Alasmari |
| author_facet | Ghassan Abdulrahman Sukkar Syed Sameer Aga Abdulrahman Hamid Alsamadani Faisal Ghazi Almalki Ali Saleh Alsudais Abdulrahman Sulaiman Alquzi Mohamed Eldigire Ahmed Mushtaq Ahmad Mir Moudi M. Alasmari |
| author_sort | Ghassan Abdulrahman Sukkar |
| collection | DOAJ |
| description | Background. The prevalence of Clostridium difficile infection (CDI) as a common complication among inflammatory bowel disease (IBD) has been reported to increase worldwide and has been associated with a poor IBD outcome. Objectives. In this study, our aim was to report on the prevalence of CDI among IBD vs. non-IBD patients in King Abdulaziz Medical City (KAMC). Methods. This retrospective descriptive study was carried out between 2016 and 2020. Data of 89 patients reported with CDI in KAMC were analyzed for demographics and correlations between various characteristics such as BMI, personal/family history of IBD, infection with CDI, diagnosis, method of diagnosis, and treatment modalities. Results. Of the total 89 CDI patients, 59 (66.3%) were adults and 30 (33.7%) were pediatric, of which 36 (40.4%) were females and 53 (59.6%) were males. PCR was the main method of choice for the diagnosis of CDI (89.9%) followed by a positive-culture result (10.0%). Seventy-eight (87.6%) CDI patients were found to be immunocompromised, with two patients diagnosed with IBDs, one with UC, and one with CD. The recurrence rate was 38.4 (30 patients) among the immunocompromised group in comparison to 27.2 (3 patients) in the immunocompetent group (p=0.584). Conclusion. In this study, we found that adults were more prone to CDI infection, especially within hospital settings, and most of the CDI infections occurred in immunocompromised individuals, with cancer as the most common cause of it. |
| format | Article |
| id | doaj-art-e0ac432264d145f997ee89261cd84e10 |
| institution | OA Journals |
| issn | 1687-7098 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-e0ac432264d145f997ee89261cd84e102025-08-20T02:21:29ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982023-01-01202310.1155/2023/9958104Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in JeddahGhassan Abdulrahman Sukkar0Syed Sameer Aga1Abdulrahman Hamid Alsamadani2Faisal Ghazi Almalki3Ali Saleh Alsudais4Abdulrahman Sulaiman Alquzi5Mohamed Eldigire Ahmed6Mushtaq Ahmad Mir7Moudi M. Alasmari8Department of PediatricDepartment of Basic Medical SciencesDepartment of Basic Medical SciencesDepartment of Basic Medical SciencesDepartment of Basic Medical SciencesDepartment of Basic Medical SciencesCollege of Science and Health ProfessionsDepartment of Clinical Laboratory ScienceDepartment of Basic Medical SciencesBackground. The prevalence of Clostridium difficile infection (CDI) as a common complication among inflammatory bowel disease (IBD) has been reported to increase worldwide and has been associated with a poor IBD outcome. Objectives. In this study, our aim was to report on the prevalence of CDI among IBD vs. non-IBD patients in King Abdulaziz Medical City (KAMC). Methods. This retrospective descriptive study was carried out between 2016 and 2020. Data of 89 patients reported with CDI in KAMC were analyzed for demographics and correlations between various characteristics such as BMI, personal/family history of IBD, infection with CDI, diagnosis, method of diagnosis, and treatment modalities. Results. Of the total 89 CDI patients, 59 (66.3%) were adults and 30 (33.7%) were pediatric, of which 36 (40.4%) were females and 53 (59.6%) were males. PCR was the main method of choice for the diagnosis of CDI (89.9%) followed by a positive-culture result (10.0%). Seventy-eight (87.6%) CDI patients were found to be immunocompromised, with two patients diagnosed with IBDs, one with UC, and one with CD. The recurrence rate was 38.4 (30 patients) among the immunocompromised group in comparison to 27.2 (3 patients) in the immunocompetent group (p=0.584). Conclusion. In this study, we found that adults were more prone to CDI infection, especially within hospital settings, and most of the CDI infections occurred in immunocompromised individuals, with cancer as the most common cause of it.http://dx.doi.org/10.1155/2023/9958104 |
| spellingShingle | Ghassan Abdulrahman Sukkar Syed Sameer Aga Abdulrahman Hamid Alsamadani Faisal Ghazi Almalki Ali Saleh Alsudais Abdulrahman Sulaiman Alquzi Mohamed Eldigire Ahmed Mushtaq Ahmad Mir Moudi M. Alasmari Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah Interdisciplinary Perspectives on Infectious Diseases |
| title | Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah |
| title_full | Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah |
| title_fullStr | Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah |
| title_full_unstemmed | Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah |
| title_short | Prevalence of Clostridium Difficile Infection (CDI) among Inflammatory Bowel Disease (IBD) Patients in Comparison to Non-IBD Patients in King Abdulaziz Medical City in Jeddah |
| title_sort | prevalence of clostridium difficile infection cdi among inflammatory bowel disease ibd patients in comparison to non ibd patients in king abdulaziz medical city in jeddah |
| url | http://dx.doi.org/10.1155/2023/9958104 |
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