Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study
PurposeTo investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.MethodsThis prospective cohort study (ChiCTR2300074104) included patients with obesity undergoing lapa...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1618630/full |
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| author | Tingwen Wang Tingwen Wang Jiaqing Huang Jiaqing Huang Xin Sun Hai Zhao Jun Bao Xuehui Chu Xiaojie Bian Xiaojie Bian |
| author_facet | Tingwen Wang Tingwen Wang Jiaqing Huang Jiaqing Huang Xin Sun Hai Zhao Jun Bao Xuehui Chu Xiaojie Bian Xiaojie Bian |
| author_sort | Tingwen Wang |
| collection | DOAJ |
| description | PurposeTo investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.MethodsThis prospective cohort study (ChiCTR2300074104) included patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG), categorized into non-mild alopecia (NM group, n = 24) and moderate–severe alopecia (MS group, n = 43) groups. Clinical data and serum amino acid concentrations were analyzed to: (1) compare preoperative and postoperative amino acid profiles; (2) evaluate amino acid differences between groups at various timepoints and correlate with alopecia severity; (3) perform logistic regression to identify alopecia risk factors.ResultsAmong 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). At 3 months postoperatively, leucine levels were higher in the MS group compared to the NM group. Spearman’s correlation analysis revealed threonine, γ-aminobutyric acid, and leucine levels were associated with alopecia severity (p < 0.05). Logistic regression identified serum leucine as an independent risk factor for postoperative alopecia (OR = 1.119, 95% CI 1.006-1.245, p = 0.038).ConclusionLSG surgery alters the serum amino acid profile in patients with obesity, and serum leucine concentration at 3 months postoperatively is an influential factor in postoperative alopecia. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e0a8a2f399e44161b6e1b395abae95b72025-08-26T04:12:43ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.16186301618630Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort studyTingwen Wang0Tingwen Wang1Jiaqing Huang2Jiaqing Huang3Xin Sun4Hai Zhao5Jun Bao6Xuehui Chu7Xiaojie Bian8Xiaojie Bian9Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Women and Children’s Healthcare Hospital, Women’s Hospital of Nanjing Medical University, Nanjing, ChinaKey Laboratory of Child Development and Learning Science of Ministry of Education of China, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, ChinaDepartment of Dermatology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Pancreatic and Metabolic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaPurposeTo investigate the association between serum amino acid changes and alopecia in patients with obesity before and after bariatric surgery, and identify risk factors for postoperative alopecia.MethodsThis prospective cohort study (ChiCTR2300074104) included patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG), categorized into non-mild alopecia (NM group, n = 24) and moderate–severe alopecia (MS group, n = 43) groups. Clinical data and serum amino acid concentrations were analyzed to: (1) compare preoperative and postoperative amino acid profiles; (2) evaluate amino acid differences between groups at various timepoints and correlate with alopecia severity; (3) perform logistic regression to identify alopecia risk factors.ResultsAmong 67 patients analyzed, LSG significantly decreased serum concentrations of arginine, alanine, threonine, glutamic acid, branched-chain amino acids (valine, isoleucine, leucine), and aromatic amino acids (tyrosine, phenylalanine, tryptophan) (p < 0.05), while serine and glycine increased (p < 0.05). At 3 months postoperatively, leucine levels were higher in the MS group compared to the NM group. Spearman’s correlation analysis revealed threonine, γ-aminobutyric acid, and leucine levels were associated with alopecia severity (p < 0.05). Logistic regression identified serum leucine as an independent risk factor for postoperative alopecia (OR = 1.119, 95% CI 1.006-1.245, p = 0.038).ConclusionLSG surgery alters the serum amino acid profile in patients with obesity, and serum leucine concentration at 3 months postoperatively is an influential factor in postoperative alopecia.https://www.frontiersin.org/articles/10.3389/fnut.2025.1618630/fullamino acidsbariatric surgeryalopecialeucineobesity |
| spellingShingle | Tingwen Wang Tingwen Wang Jiaqing Huang Jiaqing Huang Xin Sun Hai Zhao Jun Bao Xuehui Chu Xiaojie Bian Xiaojie Bian Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study Frontiers in Nutrition amino acids bariatric surgery alopecia leucine obesity |
| title | Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study |
| title_full | Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study |
| title_fullStr | Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study |
| title_full_unstemmed | Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study |
| title_short | Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study |
| title_sort | correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery a prospective cohort study |
| topic | amino acids bariatric surgery alopecia leucine obesity |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1618630/full |
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