Apoptotic vesicles of mesenchymal stem cells promote M2 polarization and alleviate early-onset preeclampsia via miR-191-5p

Apoptotic vesicles of mesenchymal stem cells promote M2 polarization and alleviate early-onset preeclampsia via miR-191-5p

Abstract Background Macrophages play a crucial role in the development of early-onset preeclampsia (EOPE), which may be closely associated with an imbalance in macrophage M1/M2 polarization. Mesenchymal stem cell (MSC)-derived apoptotic vesicles (apoVs) have anti-inflammatory, tissue repair, and imm...

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Bibliographic Details
Main Authors: Ling Li, Xu Lu, Qinghai Lian, Xiaoyun Wang, Changchang Jia, Chengfang Xu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
Early-onset preeclampsia
Mesenchymal stem cells
Apoptotic vesicles
Macrophages
MiR-191-5p
PDGF
Online Access:https://doi.org/10.1186/s13287-025-04546-5
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