Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy
Abstract Introduction Carboxymethylcellulose/polyethylene oxide, also known as Oxiplex gel, is commonly used during lumbar discectomy operations. It serves to cover the surgical site, preventing adhesions and providing relief from pain and symptoms. However, there is ongoing debate regarding the ext...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-06-01
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| Series: | Egyptian Journal of Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41984-024-00266-9 |
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| author | Alireza Tabibkhooei Maziar Azar Mohsen Nabiuni Javad Jahandideh Mohsen Benam Farid Qoorchi Moheb Seraj Feizollah Ebrahimnia Ali Moradi |
| author_facet | Alireza Tabibkhooei Maziar Azar Mohsen Nabiuni Javad Jahandideh Mohsen Benam Farid Qoorchi Moheb Seraj Feizollah Ebrahimnia Ali Moradi |
| author_sort | Alireza Tabibkhooei |
| collection | DOAJ |
| description | Abstract Introduction Carboxymethylcellulose/polyethylene oxide, also known as Oxiplex gel, is commonly used during lumbar discectomy operations. It serves to cover the surgical site, preventing adhesions and providing relief from pain and symptoms. However, there is ongoing debate regarding the extent of its beneficial effects on postoperative pain intensity, level of disability, and overall improvement of musculoskeletal conditions. Therefore, the objective of this study is to evaluate the advantages and limitations of using Oxiplex gel in lumbar laminectomy procedures specifically for herniated discs. Methods A randomized controlled trial was conducted on 56 consecutive patients who were candidates for unilateral lumbar discectomy on one lumbar surface. The patients were chosen based on their clinical manifestations and imaging findings. After the initial assessment, the patients underwent either laminectomy or laminotomy surgery. Following the surgery, the patients were randomly assigned to either the intervention group (receiving Oxiplex gel) or the control group. This assignment was done using a computerized random number generator. Assessments were conducted before the operation, as well as 3 and 6 months post-surgery for all patients. Results There was no significant difference found between the Oxiplex gel and control groups in terms of radicular and low back pain intensity, as well as disability scores, at different time points after surgery (p = 0.336, p = 0.65, and p = 0.336, respectively). Additionally, there were no significant differences found in the prevalence of sexual or sphincteric disorders between the two groups during postoperative assessments (p = 0.639 and p = 0.15, respectively). Furthermore, no significant differences were observed in the results of the postsurgical neuromuscular evaluation under different lower extremities conditions between the two groups. Conclusions Based on our findings, it was observed that Oxiplex gel did not demonstrate any improvement in post-unilateral lumbar discectomy symptoms or musculoskeletal power. |
| format | Article |
| id | doaj-art-e0a5e8f2211c4f82a9826a654d229898 |
| institution | Kabale University |
| issn | 2520-8225 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Neurosurgery |
| spelling | doaj-art-e0a5e8f2211c4f82a9826a654d2298982025-02-02T12:12:54ZengSpringerOpenEgyptian Journal of Neurosurgery2520-82252024-06-013911810.1186/s41984-024-00266-9Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomyAlireza Tabibkhooei0Maziar Azar1Mohsen Nabiuni2Javad Jahandideh3Mohsen Benam4Farid Qoorchi Moheb Seraj5Feizollah Ebrahimnia6Ali Moradi7Department of Neurosurgery, Iran University of Medical SciencesDepartment of Neurosurgery, Iran University of Medical SciencesDepartment of Neurosurgery, Iran University of Medical SciencesDepartment of Neurosurgery, Qazvin University of Medical SciencesDepartment of Neurosurgery, Iran University of Medical SciencesSection of Neurovascular Intervention, Neurosurgical Department, Ghaem Hospital, Mashhad University of Medical SciencesSection of Neurovascular Intervention, Neurosurgical Department, Ghaem Hospital, Mashhad University of Medical SciencesClinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical SciencesAbstract Introduction Carboxymethylcellulose/polyethylene oxide, also known as Oxiplex gel, is commonly used during lumbar discectomy operations. It serves to cover the surgical site, preventing adhesions and providing relief from pain and symptoms. However, there is ongoing debate regarding the extent of its beneficial effects on postoperative pain intensity, level of disability, and overall improvement of musculoskeletal conditions. Therefore, the objective of this study is to evaluate the advantages and limitations of using Oxiplex gel in lumbar laminectomy procedures specifically for herniated discs. Methods A randomized controlled trial was conducted on 56 consecutive patients who were candidates for unilateral lumbar discectomy on one lumbar surface. The patients were chosen based on their clinical manifestations and imaging findings. After the initial assessment, the patients underwent either laminectomy or laminotomy surgery. Following the surgery, the patients were randomly assigned to either the intervention group (receiving Oxiplex gel) or the control group. This assignment was done using a computerized random number generator. Assessments were conducted before the operation, as well as 3 and 6 months post-surgery for all patients. Results There was no significant difference found between the Oxiplex gel and control groups in terms of radicular and low back pain intensity, as well as disability scores, at different time points after surgery (p = 0.336, p = 0.65, and p = 0.336, respectively). Additionally, there were no significant differences found in the prevalence of sexual or sphincteric disorders between the two groups during postoperative assessments (p = 0.639 and p = 0.15, respectively). Furthermore, no significant differences were observed in the results of the postsurgical neuromuscular evaluation under different lower extremities conditions between the two groups. Conclusions Based on our findings, it was observed that Oxiplex gel did not demonstrate any improvement in post-unilateral lumbar discectomy symptoms or musculoskeletal power.https://doi.org/10.1186/s41984-024-00266-9DiscectomyLaminectomyOxiples/SP |
| spellingShingle | Alireza Tabibkhooei Maziar Azar Mohsen Nabiuni Javad Jahandideh Mohsen Benam Farid Qoorchi Moheb Seraj Feizollah Ebrahimnia Ali Moradi Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy Egyptian Journal of Neurosurgery Discectomy Laminectomy Oxiples/SP |
| title | Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy |
| title_full | Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy |
| title_fullStr | Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy |
| title_full_unstemmed | Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy |
| title_short | Early and midterm efficacy of oxiplex gel on postoperative pain intensity, physical disability, and musculoskeletal power in patients undergoing lumbar discectomy |
| title_sort | early and midterm efficacy of oxiplex gel on postoperative pain intensity physical disability and musculoskeletal power in patients undergoing lumbar discectomy |
| topic | Discectomy Laminectomy Oxiples/SP |
| url | https://doi.org/10.1186/s41984-024-00266-9 |
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