Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke
Ischemic stroke remains a leading global cause of mortality and long-term disability, imposing substantial health and economic burdens on society. Although interventions such as intravenous thrombolysis and mechanical thrombectomy have proven effective, their narrow therapeutic time window restricts...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1603417/full |
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| author | Pingping Niu Pingping Niu Yonggang Zhang Binghao Wang Sheng Qiu Quanming Dong Quanming Dong Liqin Li Yuntao Li |
| author_facet | Pingping Niu Pingping Niu Yonggang Zhang Binghao Wang Sheng Qiu Quanming Dong Quanming Dong Liqin Li Yuntao Li |
| author_sort | Pingping Niu |
| collection | DOAJ |
| description | Ischemic stroke remains a leading global cause of mortality and long-term disability, imposing substantial health and economic burdens on society. Although interventions such as intravenous thrombolysis and mechanical thrombectomy have proven effective, their narrow therapeutic time window restricts accessibility for many patients. Post-ischemic brain injury is significantly driven by a cascade involving inflammatory cells and mediators, culminating in an “inflammatory storm” that damages neuronal cells. Consequently, targeting neuroinflammation following ischemic stroke to explore potential therapeutic strategies is of paramount importance. Natural plant compounds, bioactive constituents derived from plants, demonstrate considerable promise for ischemic stroke treatment, with many exhibiting potent neuroinflammation-modulating activities. This review synthesizes current research on natural plant compounds targeting post-ischemic stroke neuroinflammation and elucidates their underlying mechanisms of action. It aims to offer insights for developing plant-derived therapeutics specifically targeting neuroinflammation after ischemic stroke. |
| format | Article |
| id | doaj-art-e0a570c5eb4845259fca2f3b2d0f6301 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e0a570c5eb4845259fca2f3b2d0f63012025-08-20T02:39:41ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16034171603417Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic strokePingping Niu0Pingping Niu1Yonggang Zhang2Binghao Wang3Sheng Qiu4Quanming Dong5Quanming Dong6Liqin Li7Yuntao Li8Department of Neurosurgery, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaScientific Research Department, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaDepartment of Neurosurgery, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaDepartment of Neurosurgery, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaDepartment of Neurosurgery, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaScientific Research Department, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaScientific Research Department, Zhejiang Chinese Medical University, Hangzhou, ChinaScientific Research Department, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaDepartment of Neurosurgery, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, ChinaIschemic stroke remains a leading global cause of mortality and long-term disability, imposing substantial health and economic burdens on society. Although interventions such as intravenous thrombolysis and mechanical thrombectomy have proven effective, their narrow therapeutic time window restricts accessibility for many patients. Post-ischemic brain injury is significantly driven by a cascade involving inflammatory cells and mediators, culminating in an “inflammatory storm” that damages neuronal cells. Consequently, targeting neuroinflammation following ischemic stroke to explore potential therapeutic strategies is of paramount importance. Natural plant compounds, bioactive constituents derived from plants, demonstrate considerable promise for ischemic stroke treatment, with many exhibiting potent neuroinflammation-modulating activities. This review synthesizes current research on natural plant compounds targeting post-ischemic stroke neuroinflammation and elucidates their underlying mechanisms of action. It aims to offer insights for developing plant-derived therapeutics specifically targeting neuroinflammation after ischemic stroke.https://www.frontiersin.org/articles/10.3389/fphar.2025.1603417/fullischemic strokenatural plant compoundsneuroinflammationneuroprotectiveanti-inflammation |
| spellingShingle | Pingping Niu Pingping Niu Yonggang Zhang Binghao Wang Sheng Qiu Quanming Dong Quanming Dong Liqin Li Yuntao Li Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke Frontiers in Pharmacology ischemic stroke natural plant compounds neuroinflammation neuroprotective anti-inflammation |
| title | Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke |
| title_full | Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke |
| title_fullStr | Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke |
| title_full_unstemmed | Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke |
| title_short | Modulation of neuroinflammation by natural plant compounds: a promising approach for ischemic stroke |
| title_sort | modulation of neuroinflammation by natural plant compounds a promising approach for ischemic stroke |
| topic | ischemic stroke natural plant compounds neuroinflammation neuroprotective anti-inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1603417/full |
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