TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.
Amebic liver abscess (ALA) is a focal destruction of liver tissue due to infection by the protozoan parasite Entamoeba histolytica (E. histolytica). Host tissue damage is attributed mainly to parasite pathogenicity factors, but massive early accumulation of mononuclear cells, including neutrophils,...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003096&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850190270305402880 |
|---|---|
| author | Elena Helk Hannah Bernin Thomas Ernst Harald Ittrich Thomas Jacobs Joerg Heeren Frank Tacke Egbert Tannich Hannelore Lotter |
| author_facet | Elena Helk Hannah Bernin Thomas Ernst Harald Ittrich Thomas Jacobs Joerg Heeren Frank Tacke Egbert Tannich Hannelore Lotter |
| author_sort | Elena Helk |
| collection | DOAJ |
| description | Amebic liver abscess (ALA) is a focal destruction of liver tissue due to infection by the protozoan parasite Entamoeba histolytica (E. histolytica). Host tissue damage is attributed mainly to parasite pathogenicity factors, but massive early accumulation of mononuclear cells, including neutrophils, inflammatory monocytes and macrophages, at the site of infection raises the question of whether these cells also contribute to tissue damage. Using highly selective depletion strategies and cell-specific knockout mice, the relative contribution of innate immune cell populations to liver destruction during amebic infection was investigated. Neutrophils were not required for amebic infection nor did they appear to be substantially involved in tissue damage. In contrast, Kupffer cells and inflammatory monocytes contributed substantially to liver destruction during ALA, and tissue damage was mediated primarily by TNFα. These data indicate that besides direct antiparasitic drugs, modulating innate immune responses may potentially be beneficial in limiting ALA pathogenesis. |
| format | Article |
| id | doaj-art-e0a43c2f06314f318074b4a48be19384 |
| institution | OA Journals |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-e0a43c2f06314f318074b4a48be193842025-08-20T02:15:20ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-01-0191e100309610.1371/journal.ppat.1003096TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.Elena HelkHannah BerninThomas ErnstHarald IttrichThomas JacobsJoerg HeerenFrank TackeEgbert TannichHannelore LotterAmebic liver abscess (ALA) is a focal destruction of liver tissue due to infection by the protozoan parasite Entamoeba histolytica (E. histolytica). Host tissue damage is attributed mainly to parasite pathogenicity factors, but massive early accumulation of mononuclear cells, including neutrophils, inflammatory monocytes and macrophages, at the site of infection raises the question of whether these cells also contribute to tissue damage. Using highly selective depletion strategies and cell-specific knockout mice, the relative contribution of innate immune cell populations to liver destruction during amebic infection was investigated. Neutrophils were not required for amebic infection nor did they appear to be substantially involved in tissue damage. In contrast, Kupffer cells and inflammatory monocytes contributed substantially to liver destruction during ALA, and tissue damage was mediated primarily by TNFα. These data indicate that besides direct antiparasitic drugs, modulating innate immune responses may potentially be beneficial in limiting ALA pathogenesis.https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003096&type=printable |
| spellingShingle | Elena Helk Hannah Bernin Thomas Ernst Harald Ittrich Thomas Jacobs Joerg Heeren Frank Tacke Egbert Tannich Hannelore Lotter TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. PLoS Pathogens |
| title | TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. |
| title_full | TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. |
| title_fullStr | TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. |
| title_full_unstemmed | TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. |
| title_short | TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection. |
| title_sort | tnfα mediated liver destruction by kupffer cells and ly6chi monocytes during entamoeba histolytica infection |
| url | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003096&type=printable |
| work_keys_str_mv | AT elenahelk tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT hannahbernin tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT thomasernst tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT haraldittrich tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT thomasjacobs tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT joergheeren tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT franktacke tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT egberttannich tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection AT hannelorelotter tnfamediatedliverdestructionbykupffercellsandly6chimonocytesduringentamoebahistolyticainfection |