Design of a polarization insensitive SPR biosensor for malaria and cancer detection
A polarization-insensitive photonic crystal fiber (PI-PCF) based surface plasmon resonance (SPR) biosensor is designed and analyzed for multianalyte detection. In this work, a simple symmetrical structure is designed using only eight circular-shaped air holes, which makes it not only polarization-in...
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Elsevier
2025-08-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180425001102 |
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| author | Hasan Masud Khan Shah Laheen Mashahad Md. Asiful Islam M. Shah Alam |
| author_facet | Hasan Masud Khan Shah Laheen Mashahad Md. Asiful Islam M. Shah Alam |
| author_sort | Hasan Masud Khan |
| collection | DOAJ |
| description | A polarization-insensitive photonic crystal fiber (PI-PCF) based surface plasmon resonance (SPR) biosensor is designed and analyzed for multianalyte detection. In this work, a simple symmetrical structure is designed using only eight circular-shaped air holes, which makes it not only polarization-insensitive (PI) but also fabrication friendly and reliable. Tantalum pentaoxide (Ta2O5) is used with gold (Au) as the plasmonic material to increase SPR excitation, solve adhesion issues, and minimize the reliance on gold. The analytes are placed on the periphery to facilitate the operation of the sensor. The numerical investigations are conducted using the full-vector finite element method (FEM) based COMSOL Multiphysics software to obtain modal solutions (effective refractive index, field distribution) of core and plasmonic modes of the sensor structure. By optimizing its structural parameters, the sensor has demonstrated a maximum wavelength sensitivity (WS) of 65,000 nm/RIU, amplitude sensitivity (AS) of 3709.66 RIU−1, and figure of merit (FOM) of 1160.71 RIU−1, sensor resolution (SR) of 1.53 × 10−6 RIU, for both x and y-polarizations to detect unknown analyte refractive indices (RIs) from 1.28 to 1.42. Furthermore, the sensor can be used to detect different phases of malaria disease, including ring, schizont and trophozoite phases; it shows the WS of 10,000 nm/RIU for the ring phase and the AS of 2042.77 RIU−1 for the trophozoite phase. Moreover, it can detect six distinct varieties of cancer cells, with WS of 7857.14 nm/RIU for breast (MCF-7) and AS of 5281.01 RIU−1 for cervical (HeLa). The sensor's sensitivity is not significantly affected by air hole dimensions, ensuring high structural tolerance. Its exceptional performance and favorable manufacturing likelihood make it a valuable candidate for biological, biomedical, and biochemical analyte sensing application. |
| format | Article |
| id | doaj-art-e0a311462bd34059b1df5a8b349d8743 |
| institution | Kabale University |
| issn | 2214-1804 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj-art-e0a311462bd34059b1df5a8b349d87432025-08-20T03:50:53ZengElsevierSensing and Bio-Sensing Research2214-18042025-08-014910084410.1016/j.sbsr.2025.100844Design of a polarization insensitive SPR biosensor for malaria and cancer detectionHasan Masud Khan0Shah Laheen Mashahad1Md. Asiful Islam2M. Shah Alam3Department of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology, Dhaka 1205, BangladeshDepartment of Electrical and Electronic Engineering, Islamic University of Technology, Boardbazar, Gazipur, BangladeshDepartment of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology, Dhaka 1205, BangladeshDepartment of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology, Dhaka 1205, Bangladesh; Corresponding author.A polarization-insensitive photonic crystal fiber (PI-PCF) based surface plasmon resonance (SPR) biosensor is designed and analyzed for multianalyte detection. In this work, a simple symmetrical structure is designed using only eight circular-shaped air holes, which makes it not only polarization-insensitive (PI) but also fabrication friendly and reliable. Tantalum pentaoxide (Ta2O5) is used with gold (Au) as the plasmonic material to increase SPR excitation, solve adhesion issues, and minimize the reliance on gold. The analytes are placed on the periphery to facilitate the operation of the sensor. The numerical investigations are conducted using the full-vector finite element method (FEM) based COMSOL Multiphysics software to obtain modal solutions (effective refractive index, field distribution) of core and plasmonic modes of the sensor structure. By optimizing its structural parameters, the sensor has demonstrated a maximum wavelength sensitivity (WS) of 65,000 nm/RIU, amplitude sensitivity (AS) of 3709.66 RIU−1, and figure of merit (FOM) of 1160.71 RIU−1, sensor resolution (SR) of 1.53 × 10−6 RIU, for both x and y-polarizations to detect unknown analyte refractive indices (RIs) from 1.28 to 1.42. Furthermore, the sensor can be used to detect different phases of malaria disease, including ring, schizont and trophozoite phases; it shows the WS of 10,000 nm/RIU for the ring phase and the AS of 2042.77 RIU−1 for the trophozoite phase. Moreover, it can detect six distinct varieties of cancer cells, with WS of 7857.14 nm/RIU for breast (MCF-7) and AS of 5281.01 RIU−1 for cervical (HeLa). The sensor's sensitivity is not significantly affected by air hole dimensions, ensuring high structural tolerance. Its exceptional performance and favorable manufacturing likelihood make it a valuable candidate for biological, biomedical, and biochemical analyte sensing application.http://www.sciencedirect.com/science/article/pii/S2214180425001102Photonic crystal fiberSurface plasmon resonanceBiosensorcancer cell detectionMalaria disease detection |
| spellingShingle | Hasan Masud Khan Shah Laheen Mashahad Md. Asiful Islam M. Shah Alam Design of a polarization insensitive SPR biosensor for malaria and cancer detection Sensing and Bio-Sensing Research Photonic crystal fiber Surface plasmon resonance Biosensor cancer cell detection Malaria disease detection |
| title | Design of a polarization insensitive SPR biosensor for malaria and cancer detection |
| title_full | Design of a polarization insensitive SPR biosensor for malaria and cancer detection |
| title_fullStr | Design of a polarization insensitive SPR biosensor for malaria and cancer detection |
| title_full_unstemmed | Design of a polarization insensitive SPR biosensor for malaria and cancer detection |
| title_short | Design of a polarization insensitive SPR biosensor for malaria and cancer detection |
| title_sort | design of a polarization insensitive spr biosensor for malaria and cancer detection |
| topic | Photonic crystal fiber Surface plasmon resonance Biosensor cancer cell detection Malaria disease detection |
| url | http://www.sciencedirect.com/science/article/pii/S2214180425001102 |
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