Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study
Introduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, re...
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BMJ Publishing Group
2018-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/8/5/e018317.full |
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| author | Frederic Dutheil Dahlia Tharwat Marion Trousselard Mélanie Balès Anne-Laure Sutter-Dallay Dominique Fromage Elisabeth Spitz Dominique Dallay Thierry Harvey Eric Welter Frédéric Coatleven Lydie Cherier Frédérique Teissèdre Jean-Luc Pouly Anaïs M Duffaud |
| author_facet | Frederic Dutheil Dahlia Tharwat Marion Trousselard Mélanie Balès Anne-Laure Sutter-Dallay Dominique Fromage Elisabeth Spitz Dominique Dallay Thierry Harvey Eric Welter Frédéric Coatleven Lydie Cherier Frédérique Teissèdre Jean-Luc Pouly Anaïs M Duffaud |
| author_sort | Frederic Dutheil |
| collection | DOAJ |
| description | Introduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies.In this article, we present the protocol of an ongoing study (started in May 2017).Methods and analysis The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery.Ethics and dissemination Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals.Trial registration number NCT03088319; Pre-results. |
| format | Article |
| id | doaj-art-e0a05296cf3848aaaa27e66f320ca389 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2018-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e0a05296cf3848aaaa27e66f320ca3892025-08-20T02:11:22ZengBMJ Publishing GroupBMJ Open2044-60552018-05-018510.1136/bmjopen-2017-018317Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory studyFrederic Dutheil0Dahlia Tharwat1Marion Trousselard2Mélanie Balès3Anne-Laure Sutter-Dallay4Dominique Fromage5Elisabeth Spitz6Dominique Dallay7Thierry Harvey8Eric Welter9Frédéric Coatleven10Lydie Cherier11Frédérique Teissèdre12Jean-Luc Pouly13Anaïs M Duffaud14Faculty of Health, Australian Catholic University, Melbourne, Victoria, AustraliaMaternité GH Diaconesses Croix St Simon, Paris, FranceArmies` Health Service, Bretigny sur Orge, FranceINSERM 1219, EPS Charles Perrens et Centre de RecherchE, Bordeaux, FranceINSERM 1219, EPS Charles Perrens et Centre de RecherchE, Bordeaux, FranceUnité de Neurophysiologie du Stress, Département Neurosciences et Contraintes Opérationnelles, Institute de Recherche Biomédicale des Armées, Brétigny Sur Orge, FranceApemac, University of Lorraine, Vandoeuvre-lès-Nancy, FranceCentre Aliénor d’Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, FranceMaternité GH Diaconesses Croix St Simon, Paris, FranceCHR Mercy, Regional Hospital of Metz, Metz, FranceCentre Aliénor d’Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, FranceCentre Aliénor d’Aquitaine, CHU Pellegrin, University Hospital of Bordeaux, Bordeaux, FranceDepartment of In-Vitro Fecondation, Gynecologia, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Clermont-Ferrand, FranceUniversité Clermont Auvergne, UMR CNRS 6024, LaPSCo, Physiological and Psychosocial Stress, CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Occupational and Preventive Medicine, Clermont-Ferrand, FranceUnité de Neurophysiologie du Stress, Département Neurosciences et Contraintes Opérationnelles, Institute de Recherche Biomédicale des Armées, Brétigny Sur Orge, FranceIntroduction The prevalence of postnatal depression (PND) is significant: reaching up to 20% in the general population. In mechanistic terms, the risk of PND lies in an interaction between a maternal psychophysiological vulnerability and a chronic environmental context of stress. On the one hand, repetition of stressor during pregnancy mimics a chronic stress model that is relevant to the study of the allostatic load and the adaptive mechanisms. On the other hand, vulnerability factors reflect a psychological profile mirroring mindfulness functioning (psychological quality that involves bringing one’s complete and non-judgemental attention to the present experience on a moment-to-moment basis). This psychological resource is linked to protective and resilient psychic functioning. Thus, PND appears to be a relevant model for studying the mechanisms of chronic stress and vulnerability to psychopathologies.In this article, we present the protocol of an ongoing study (started in May 2017).Methods and analysis The study is being carried out in five maternities and will involve 260 women. We aim to determine the predictive psychobiological factors for PND emergence and to provide a better insight into the mechanisms involved in chronic stress during pregnancy. We use a multidisciplinary approach that encompasses psychological resources and biophysiological and genetic profiles in order to detect relevant vulnerability biomarkers for chronic stress and the development of PND. To do so, each woman will be involved in the study from her first trimester of pregnancy until 12 months postdelivery.Ethics and dissemination Ethics approval was obtained from the Ile de France III Ethics Committee, France (2016-A00887-44). We aim to disseminate the findings through international conferences and international peer-reviewed journals.Trial registration number NCT03088319; Pre-results.https://bmjopen.bmj.com/content/8/5/e018317.full |
| spellingShingle | Frederic Dutheil Dahlia Tharwat Marion Trousselard Mélanie Balès Anne-Laure Sutter-Dallay Dominique Fromage Elisabeth Spitz Dominique Dallay Thierry Harvey Eric Welter Frédéric Coatleven Lydie Cherier Frédérique Teissèdre Jean-Luc Pouly Anaïs M Duffaud Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study BMJ Open |
| title | Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study |
| title_full | Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study |
| title_fullStr | Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study |
| title_full_unstemmed | Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study |
| title_short | Chronic Stress protection for postnatal dEpREssioN prEvention (SERENE): a protocol for an exploratory study |
| title_sort | chronic stress protection for postnatal depression prevention serene a protocol for an exploratory study |
| url | https://bmjopen.bmj.com/content/8/5/e018317.full |
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