Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy
Abstract Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune resp...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-024-02205-6 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544940939640832 |
|---|---|
| author | Kun Huang Ying Han Yihong Chen Hong Shen Shan Zeng Changjing Cai |
| author_facet | Kun Huang Ying Han Yihong Chen Hong Shen Shan Zeng Changjing Cai |
| author_sort | Kun Huang |
| collection | DOAJ |
| description | Abstract Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Metabolic dysregulation creates an immunosuppressive TME, impairing the antitumor immune response. In this review, we discuss how metabolic regulators affect the tumor cell and the crosstalk of TME. We also summarize recent clinical trials involving metabolic regulators and the challenges of metabolism-based tumor therapies in clinical translation. In a word, our review distills key regulatory factors and their mechanisms of action from the complex reprogramming of tumor metabolism, identified as tumor metabolic regulators. These regulators provide a theoretical basis and research direction for the development of new strategies and targets in cancer therapy based on tumor metabolic reprogramming. |
| format | Article |
| id | doaj-art-e09dd4eff1ad44bf912555d01ace70f6 |
| institution | Kabale University |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-e09dd4eff1ad44bf912555d01ace70f62025-01-12T12:10:27ZengBMCMolecular Cancer1476-45982025-01-0124112810.1186/s12943-024-02205-6Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapyKun Huang0Ying Han1Yihong Chen2Hong Shen3Shan Zeng4Changjing Cai5Department of Oncology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityDepartment of Oncology, Xiangya Hospital, Central South UniversityAbstract Metabolic reprogramming within the tumor microenvironment (TME) is a hallmark of cancer and a crucial determinant of tumor progression. Research indicates that various metabolic regulators form a metabolic network in the TME and interact with immune cells, coordinating the tumor immune response. Metabolic dysregulation creates an immunosuppressive TME, impairing the antitumor immune response. In this review, we discuss how metabolic regulators affect the tumor cell and the crosstalk of TME. We also summarize recent clinical trials involving metabolic regulators and the challenges of metabolism-based tumor therapies in clinical translation. In a word, our review distills key regulatory factors and their mechanisms of action from the complex reprogramming of tumor metabolism, identified as tumor metabolic regulators. These regulators provide a theoretical basis and research direction for the development of new strategies and targets in cancer therapy based on tumor metabolic reprogramming.https://doi.org/10.1186/s12943-024-02205-6TMEMetabolic reprogrammingMetabolic regulatorsCancer therapy |
| spellingShingle | Kun Huang Ying Han Yihong Chen Hong Shen Shan Zeng Changjing Cai Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy Molecular Cancer TME Metabolic reprogramming Metabolic regulators Cancer therapy |
| title | Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| title_full | Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| title_fullStr | Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| title_full_unstemmed | Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| title_short | Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| title_sort | tumor metabolic regulators key drivers of metabolic reprogramming and the promising targets in cancer therapy |
| topic | TME Metabolic reprogramming Metabolic regulators Cancer therapy |
| url | https://doi.org/10.1186/s12943-024-02205-6 |
| work_keys_str_mv | AT kunhuang tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy AT yinghan tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy AT yihongchen tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy AT hongshen tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy AT shanzeng tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy AT changjingcai tumormetabolicregulatorskeydriversofmetabolicreprogrammingandthepromisingtargetsincancertherapy |