The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study
Study objective: Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disorder increasingly characterized by concomitant metabolic syndrome. Cardiac rehabilitation (CR) has been shown to improve metabolic parameters in populations with heart failure and myocardial infarction. Howe...
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Elsevier
2025-02-01
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| Series: | American Heart Journal Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602225000047 |
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| author | Matthew Cheung Nathaniel Moulson Jinelle C. Gelinas Ali Daraei Sarah M. Bradwell Carolyn Taylor Neil D. Eves Graeme J. Koelwyn Thomas M. Roston |
| author_facet | Matthew Cheung Nathaniel Moulson Jinelle C. Gelinas Ali Daraei Sarah M. Bradwell Carolyn Taylor Neil D. Eves Graeme J. Koelwyn Thomas M. Roston |
| author_sort | Matthew Cheung |
| collection | DOAJ |
| description | Study objective: Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disorder increasingly characterized by concomitant metabolic syndrome. Cardiac rehabilitation (CR) has been shown to improve metabolic parameters in populations with heart failure and myocardial infarction. However, there is a paucity of data on the impact of CR in the HCM population with metabolic syndrome. We designed the REHAB-HCM study to explore the feasibility, safety, and efficacy of CR in HCM patients with metabolic syndrome. Design: Prospective observation cohort study. Setting: A multi-disciplinary HCM clinic and Multidisciplinary Exercise-based Cardiac Rehabilitation program. Participants: Patients aged 18–80 years old diagnosed with HCM and metabolic syndrome, defined by the American Heart Association and American College of Cardiology guidelines, and the National Cholesterol Education Adult Treatment Panel III (NCEP-ATP III) criteria. Intervention: A structured 3-month CR program with 6 months extended follow-up of physical activity levels. Main outcome measures: Feasibility (e.g., attendance), safety (e.g., major adverse events and exercise-related harms), and efficacy pertaining to long term improvements in physical activity levels, metabolic health, cardiorespiratory fitness, quality of life, and systemic and cellular markers of inflammation. Conclusion: This prospective cohort study will address an important knowledge gap by evaluating the effect of an organized CR program in HCM patients and metabolic syndrome. It is anticipated that exercise and CR will be feasible and beneficial for this complex patient population without significant exercise-related harms. |
| format | Article |
| id | doaj-art-e099da00ec5f48a2ac6cd87a9946f605 |
| institution | Kabale University |
| issn | 2666-6022 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj-art-e099da00ec5f48a2ac6cd87a9946f6052025-02-08T05:01:22ZengElsevierAmerican Heart Journal Plus2666-60222025-02-0150100501The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) StudyMatthew Cheung0Nathaniel Moulson1Jinelle C. Gelinas2Ali Daraei3Sarah M. Bradwell4Carolyn Taylor5Neil D. Eves6Graeme J. Koelwyn7Thomas M. Roston8Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDivision of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, CanadaCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada; Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, CanadaCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, CanadaDivision of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaCentre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, CanadaCentre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Burnaby, CanadaDivision of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Cardiovascular Innovation, Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Corresponding author at: St. Paul's Hospital, Division of Cardiology, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada.Study objective: Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disorder increasingly characterized by concomitant metabolic syndrome. Cardiac rehabilitation (CR) has been shown to improve metabolic parameters in populations with heart failure and myocardial infarction. However, there is a paucity of data on the impact of CR in the HCM population with metabolic syndrome. We designed the REHAB-HCM study to explore the feasibility, safety, and efficacy of CR in HCM patients with metabolic syndrome. Design: Prospective observation cohort study. Setting: A multi-disciplinary HCM clinic and Multidisciplinary Exercise-based Cardiac Rehabilitation program. Participants: Patients aged 18–80 years old diagnosed with HCM and metabolic syndrome, defined by the American Heart Association and American College of Cardiology guidelines, and the National Cholesterol Education Adult Treatment Panel III (NCEP-ATP III) criteria. Intervention: A structured 3-month CR program with 6 months extended follow-up of physical activity levels. Main outcome measures: Feasibility (e.g., attendance), safety (e.g., major adverse events and exercise-related harms), and efficacy pertaining to long term improvements in physical activity levels, metabolic health, cardiorespiratory fitness, quality of life, and systemic and cellular markers of inflammation. Conclusion: This prospective cohort study will address an important knowledge gap by evaluating the effect of an organized CR program in HCM patients and metabolic syndrome. It is anticipated that exercise and CR will be feasible and beneficial for this complex patient population without significant exercise-related harms.http://www.sciencedirect.com/science/article/pii/S2666602225000047Hypertrophic cardiomyopathyCardiac rehabilitationMetabolic syndromeCardiometabolic fitnessExercise therapyInflammation |
| spellingShingle | Matthew Cheung Nathaniel Moulson Jinelle C. Gelinas Ali Daraei Sarah M. Bradwell Carolyn Taylor Neil D. Eves Graeme J. Koelwyn Thomas M. Roston The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study American Heart Journal Plus Hypertrophic cardiomyopathy Cardiac rehabilitation Metabolic syndrome Cardiometabolic fitness Exercise therapy Inflammation |
| title | The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study |
| title_full | The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study |
| title_fullStr | The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study |
| title_full_unstemmed | The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study |
| title_short | The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study |
| title_sort | design and rationale of the cardiac rehabilitation to improve metabolic health in hypertrophic cardiomyopathy rehab hcm study |
| topic | Hypertrophic cardiomyopathy Cardiac rehabilitation Metabolic syndrome Cardiometabolic fitness Exercise therapy Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2666602225000047 |
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