Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps
Background Endometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo–YAP1 signalling pathway has been studied in various...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Obstetrics and Gynaecology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01443615.2025.2533965 |
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| author | Xinyu Yu Weijia Kong Kaiyue Shang Hongxin Xing Wenjing Sun Qianqian Li Hui Zhang |
| author_facet | Xinyu Yu Weijia Kong Kaiyue Shang Hongxin Xing Wenjing Sun Qianqian Li Hui Zhang |
| author_sort | Xinyu Yu |
| collection | DOAJ |
| description | Background Endometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo–YAP1 signalling pathway has been studied in various diseases. However, few studies have explored their expression in EPs and association with progesterone resistance. Prolactin (PRL), a molecular marker of endometrial mesenchymal cell metaplasia, indirectly reflects progesterone action in vivo. This study aimed to explore the role of Hippo–YAP1 signalling pathway in EPs.Methods Endometrial tissue specimens obtained by surgical resection from 35 patients with a normal endometrium and 35 with EPs were collected between July 2023 and July 2024. Immunohistochemically, the expressions of mammalian STE20-like kinase 1 (MST1), Yes-associated protein 1 (YAP1), progesterone receptor (PR) and PRL in the normal endometrium and EPs tissues were detected.Results Compared to normal endometrial tissues, the expression of MST1 was relatively low in EPs (p < .05), while the total and nuclear expression of YAP1 was relatively high in EPs (p < .0001). The expression of PR in EPs tissues was significantly lower than that in normal endometrial tissues (p < .05), and the expression level of PRL was lower than that of normal endometrium in EPs tissues (p < .001).Conclusions EPs have progesterone resistance, and the Hippo–YAP1 signalling pathway may be involved in the development and progression of EPs by acting on the progesterone resistance mechanism. |
| format | Article |
| id | doaj-art-e099ca80642940eabff4357f185a582b |
| institution | DOAJ |
| issn | 0144-3615 1364-6893 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Obstetrics and Gynaecology |
| spelling | doaj-art-e099ca80642940eabff4357f185a582b2025-08-20T03:13:49ZengTaylor & Francis GroupJournal of Obstetrics and Gynaecology0144-36151364-68932025-12-0145110.1080/01443615.2025.2533965Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polypsXinyu Yu0Weijia Kong1Kaiyue Shang2Hongxin Xing3Wenjing Sun4Qianqian Li5Hui Zhang6Department of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Obstetrics and Gynaecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaBackground Endometrial polyps (EPs) are a localised hyperproliferative disorder of the endometrium, and its pathogenesis remains unclear. Progesterone resistance may influence the recurrence rate of progesterone-treated EPs. Expression of the Hippo–YAP1 signalling pathway has been studied in various diseases. However, few studies have explored their expression in EPs and association with progesterone resistance. Prolactin (PRL), a molecular marker of endometrial mesenchymal cell metaplasia, indirectly reflects progesterone action in vivo. This study aimed to explore the role of Hippo–YAP1 signalling pathway in EPs.Methods Endometrial tissue specimens obtained by surgical resection from 35 patients with a normal endometrium and 35 with EPs were collected between July 2023 and July 2024. Immunohistochemically, the expressions of mammalian STE20-like kinase 1 (MST1), Yes-associated protein 1 (YAP1), progesterone receptor (PR) and PRL in the normal endometrium and EPs tissues were detected.Results Compared to normal endometrial tissues, the expression of MST1 was relatively low in EPs (p < .05), while the total and nuclear expression of YAP1 was relatively high in EPs (p < .0001). The expression of PR in EPs tissues was significantly lower than that in normal endometrial tissues (p < .05), and the expression level of PRL was lower than that of normal endometrium in EPs tissues (p < .001).Conclusions EPs have progesterone resistance, and the Hippo–YAP1 signalling pathway may be involved in the development and progression of EPs by acting on the progesterone resistance mechanism.https://www.tandfonline.com/doi/10.1080/01443615.2025.2533965HippoYAP1progesterone receptorPRLendometrial polyps |
| spellingShingle | Xinyu Yu Weijia Kong Kaiyue Shang Hongxin Xing Wenjing Sun Qianqian Li Hui Zhang Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps Journal of Obstetrics and Gynaecology Hippo YAP1 progesterone receptor PRL endometrial polyps |
| title | Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| title_full | Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| title_fullStr | Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| title_full_unstemmed | Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| title_short | Abnormal expression of Hippo–YAP1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| title_sort | abnormal expression of hippo yap1 signalling pathway and progesterone resistance mechanism in endometrial polyps |
| topic | Hippo YAP1 progesterone receptor PRL endometrial polyps |
| url | https://www.tandfonline.com/doi/10.1080/01443615.2025.2533965 |
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