Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy
Doxorubicin – basic drug for the neoplastic diseases treatment, it’s main adverse effect is cardiotoxicity. The development of this complication is connected with the energy metabolism, prooxidant-antioxidant homeostasis, disturbances and influence on the genetic apparatus. The aim of the study –...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-08-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/50299/47696 |
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| author | E. A. Raketskaya I. S. Chekman N. A. Gorchakova |
| author_facet | E. A. Raketskaya I. S. Chekman N. A. Gorchakova |
| author_sort | E. A. Raketskaya |
| collection | DOAJ |
| description | Doxorubicin – basic drug for the neoplastic diseases treatment, it’s main adverse effect is cardiotoxicity. The development of this complication is connected with the energy metabolism, prooxidant-antioxidant homeostasis, disturbances and influence on the genetic apparatus.
The aim of the study – to state the succin acid’ derivatives – yakton and mexicor influence on indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy.
Results. In was found that myocardial pyruvate, malate, isocitrate, glycogen, glucose-6-phosphate level and malatdegidrogenase activity were decreased in rats with doxorubicin cardiomyopathy. In comparison lactate lactate level increased.
Conclusion. Succin acid’ derivatives – yakton and mexicor, administering with doxorubicin, protect glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium. |
| format | Article |
| id | doaj-art-e0987665b9684f7abc3abe03359c292b |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2015-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-e0987665b9684f7abc3abe03359c292b2025-08-20T02:03:57ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-08-0144951http://dx.doi.org/10.14739/2310-1210.2015.4.50299Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathyE. A. RaketskayaI. S. ChekmanN. A. GorchakovaDoxorubicin – basic drug for the neoplastic diseases treatment, it’s main adverse effect is cardiotoxicity. The development of this complication is connected with the energy metabolism, prooxidant-antioxidant homeostasis, disturbances and influence on the genetic apparatus. The aim of the study – to state the succin acid’ derivatives – yakton and mexicor influence on indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy. Results. In was found that myocardial pyruvate, malate, isocitrate, glycogen, glucose-6-phosphate level and malatdegidrogenase activity were decreased in rats with doxorubicin cardiomyopathy. In comparison lactate lactate level increased. Conclusion. Succin acid’ derivatives – yakton and mexicor, administering with doxorubicin, protect glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium.http://zmj.zsmu.edu.ua/article/view/50299/47696YaktonMexicorGlycolysisGlyconeogenesisHeart Mitochondria |
| spellingShingle | E. A. Raketskaya I. S. Chekman N. A. Gorchakova Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy Zaporožskij Medicinskij Žurnal Yakton Mexicor Glycolysis Glyconeogenesis Heart Mitochondria |
| title | Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy |
| title_full | Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy |
| title_fullStr | Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy |
| title_full_unstemmed | Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy |
| title_short | Yakton and mexicor influence on the indicators of glycolysis, glyconeogenesis and energoproduct function of mitochondria in the rats’ myocardium in the conditions of doxorubicin cardiomyopathy |
| title_sort | yakton and mexicor influence on the indicators of glycolysis glyconeogenesis and energoproduct function of mitochondria in the rats myocardium in the conditions of doxorubicin cardiomyopathy |
| topic | Yakton Mexicor Glycolysis Glyconeogenesis Heart Mitochondria |
| url | http://zmj.zsmu.edu.ua/article/view/50299/47696 |
| work_keys_str_mv | AT earaketskaya yaktonandmexicorinfluenceontheindicatorsofglycolysisglyconeogenesisandenergoproductfunctionofmitochondriaintheratsmyocardiumintheconditionsofdoxorubicincardiomyopathy AT ischekman yaktonandmexicorinfluenceontheindicatorsofglycolysisglyconeogenesisandenergoproductfunctionofmitochondriaintheratsmyocardiumintheconditionsofdoxorubicincardiomyopathy AT nagorchakova yaktonandmexicorinfluenceontheindicatorsofglycolysisglyconeogenesisandenergoproductfunctionofmitochondriaintheratsmyocardiumintheconditionsofdoxorubicincardiomyopathy |