Microglia: An Active Player in the Regulation of Synaptic Activity
Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is cr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/627325 |
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| _version_ | 1850166321049763840 |
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| author | Kyungmin Ji Jeremy Miyauchi Stella E. Tsirka |
| author_facet | Kyungmin Ji Jeremy Miyauchi Stella E. Tsirka |
| author_sort | Kyungmin Ji |
| collection | DOAJ |
| description | Synaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination. |
| format | Article |
| id | doaj-art-e0958f7c135e449fbe9a473158799081 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e0958f7c135e449fbe9a4731587990812025-08-20T02:21:29ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/627325627325Microglia: An Active Player in the Regulation of Synaptic ActivityKyungmin Ji0Jeremy Miyauchi1Stella E. Tsirka2Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794-8651, USADepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794-8651, USADepartment of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794-8651, USASynaptic plasticity is critical for elaboration and adaptation in the developing and developed brain. It is well established that astrocytes play an important role in the maintenance of what has been dubbed “the tripartite synapse”. Increasing evidence shows that a fourth cell type, microglia, is critical to this maintenance as well. Microglia are the resident macrophages of the central nervous system (CNS). Because of their well-characterized inflammatory functions, research has primarily focused on their innate immune properties. The role of microglia in the maintenance of synapses in development and in homeostasis is not as well defined. A number of significant findings have shed light on the critical role of microglia at the synapse. It is becoming increasingly clear that microglia play a seminal role in proper synaptic development and elimination.http://dx.doi.org/10.1155/2013/627325 |
| spellingShingle | Kyungmin Ji Jeremy Miyauchi Stella E. Tsirka Microglia: An Active Player in the Regulation of Synaptic Activity Neural Plasticity |
| title | Microglia: An Active Player in the Regulation of Synaptic Activity |
| title_full | Microglia: An Active Player in the Regulation of Synaptic Activity |
| title_fullStr | Microglia: An Active Player in the Regulation of Synaptic Activity |
| title_full_unstemmed | Microglia: An Active Player in the Regulation of Synaptic Activity |
| title_short | Microglia: An Active Player in the Regulation of Synaptic Activity |
| title_sort | microglia an active player in the regulation of synaptic activity |
| url | http://dx.doi.org/10.1155/2013/627325 |
| work_keys_str_mv | AT kyungminji microgliaanactiveplayerintheregulationofsynapticactivity AT jeremymiyauchi microgliaanactiveplayerintheregulationofsynapticactivity AT stellaetsirka microgliaanactiveplayerintheregulationofsynapticactivity |