Clinical laboratory aspects of one-component immunosuppression during liver transplantation
Clinical laboratory results were analyzed in patients on one- and two-component suppression in the late period after liver transplantation.Objective: to study the impact of one-component immunosuppression with calcineurin inhibitors on clinical laboratory parameters in the late period after liver tr...
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2018-08-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/260 |
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| author | M. Sh. Khubutia V. P. Nikulina M. A. Godkov V. E. Syutkin O. I. Andreitseva A. V. Chzhao |
| author_facet | M. Sh. Khubutia V. P. Nikulina M. A. Godkov V. E. Syutkin O. I. Andreitseva A. V. Chzhao |
| author_sort | M. Sh. Khubutia |
| collection | DOAJ |
| description | Clinical laboratory results were analyzed in patients on one- and two-component suppression in the late period after liver transplantation.Objective: to study the impact of one-component immunosuppression with calcineurin inhibitors on clinical laboratory parameters in the late period after liver transplantation.Subjects and methods. Examinations were made in 3 groups of patients receiving various immunosuppressive therapy regimens: 1) 15 took cyclosporine; 2) 10 had tacrolimus; 3) 8 received a calcineurin inhibitor and a mycophenolic acid preparation. Their peripheral blood samples were biochemically and immunologically studied.Results. Hyperglycemia was detected in 5 (38.5%) patients receiving tacrolimus and 3 (15%) patients taking cyclosporine. Hypertension was observed in 11 (55%) patients on cyclosporine and in 3 (23%) on tacrolimus. The above complications were seen in 50% of the patients on two-component immunosuppression. Two cases of acute rejection were noted in Groups 1 (6.7%) and 3 (12.5%). The most pronounced biochemical and immunological changes were observed in the two-component immunosuppression group.Conclusion. The use of one-component immunosuppression with calcineurin inhibitors in patients after liver transplantation is effective and adequate; however, the etiology of liver cirrhosis should be taken into account on switching to one-component suppression. |
| format | Article |
| id | doaj-art-e09496da4b6b4237916392641f8bf493 |
| institution | Kabale University |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-e09496da4b6b4237916392641f8bf4932025-08-20T03:35:37ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092018-08-0102253110.23873/2074-0506-2009-0-2-25-31249Clinical laboratory aspects of one-component immunosuppression during liver transplantationM. Sh. Khubutia0V. P. Nikulina1M. A. Godkov2V. E. Syutkin3O. I. Andreitseva4A. V. Chzhao5Moscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryMoscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryMoscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryMoscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryMoscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryMoscow City Center of Liver Transplantation, N.V. Sklifosovsky Research Institute of Emergency Care; Moscow State University of Medicine and DentistryClinical laboratory results were analyzed in patients on one- and two-component suppression in the late period after liver transplantation.Objective: to study the impact of one-component immunosuppression with calcineurin inhibitors on clinical laboratory parameters in the late period after liver transplantation.Subjects and methods. Examinations were made in 3 groups of patients receiving various immunosuppressive therapy regimens: 1) 15 took cyclosporine; 2) 10 had tacrolimus; 3) 8 received a calcineurin inhibitor and a mycophenolic acid preparation. Their peripheral blood samples were biochemically and immunologically studied.Results. Hyperglycemia was detected in 5 (38.5%) patients receiving tacrolimus and 3 (15%) patients taking cyclosporine. Hypertension was observed in 11 (55%) patients on cyclosporine and in 3 (23%) on tacrolimus. The above complications were seen in 50% of the patients on two-component immunosuppression. Two cases of acute rejection were noted in Groups 1 (6.7%) and 3 (12.5%). The most pronounced biochemical and immunological changes were observed in the two-component immunosuppression group.Conclusion. The use of one-component immunosuppression with calcineurin inhibitors in patients after liver transplantation is effective and adequate; however, the etiology of liver cirrhosis should be taken into account on switching to one-component suppression.https://www.jtransplantologiya.ru/jour/article/view/260immunosuppressioncyclosporinetacrolimusimmunological results |
| spellingShingle | M. Sh. Khubutia V. P. Nikulina M. A. Godkov V. E. Syutkin O. I. Andreitseva A. V. Chzhao Clinical laboratory aspects of one-component immunosuppression during liver transplantation Трансплантология (Москва) immunosuppression cyclosporine tacrolimus immunological results |
| title | Clinical laboratory aspects of one-component immunosuppression during liver transplantation |
| title_full | Clinical laboratory aspects of one-component immunosuppression during liver transplantation |
| title_fullStr | Clinical laboratory aspects of one-component immunosuppression during liver transplantation |
| title_full_unstemmed | Clinical laboratory aspects of one-component immunosuppression during liver transplantation |
| title_short | Clinical laboratory aspects of one-component immunosuppression during liver transplantation |
| title_sort | clinical laboratory aspects of one component immunosuppression during liver transplantation |
| topic | immunosuppression cyclosporine tacrolimus immunological results |
| url | https://www.jtransplantologiya.ru/jour/article/view/260 |
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