New avenues of combating antibiotic resistance by targeting cryptic pockets
Antibiotic resistance is a global health concern that is rapidly spreading among human and animal pathogens. Developing novel antibiotics is one of the most significant approaches to surmount antibiotic resistance. Given the difficult in identifying novel targets, cryptic binding sites provide new p...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824004407 |
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| author | Yangyang Gao Huimin Chen Weicheng Yang Shuang Wang Daohong Gong Xiao Zhang Yuanqin Huang Vinit Kumar Qiuqian Huang W.M.W.W. Kandegama Gefei Hao |
| author_facet | Yangyang Gao Huimin Chen Weicheng Yang Shuang Wang Daohong Gong Xiao Zhang Yuanqin Huang Vinit Kumar Qiuqian Huang W.M.W.W. Kandegama Gefei Hao |
| author_sort | Yangyang Gao |
| collection | DOAJ |
| description | Antibiotic resistance is a global health concern that is rapidly spreading among human and animal pathogens. Developing novel antibiotics is one of the most significant approaches to surmount antibiotic resistance. Given the difficult in identifying novel targets, cryptic binding sites provide new pockets for compounds design to combat antibiotic resistance. However, there exists a lack of comprehensive analysis and discussion on the successful utilization of cryptic pockets in overcoming antibiotic resistance. Here, we systematically analyze the crucial role of cryptic pockets in neutralizing antibiotic resistance. First, antibiotic resistance development and associated resistance mechanisms are summarized. Then, the advantages and mechanisms of cryptic pockets for overcoming antibiotic resistance were discussed. Specific cryptic pockets in resistant proteins and successful case studies of designed inhibitors are exemplified. This review provides insight into the discovery of cryptic pockets for drug design as an approach to overcome antibiotic resistance |
| format | Article |
| id | doaj-art-e09312f1063644b7a1046f5c8018bf4e |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-e09312f1063644b7a1046f5c8018bf4e2025-08-20T02:49:40ZengElsevierPharmacological Research1096-11862024-12-0121010749510.1016/j.phrs.2024.107495New avenues of combating antibiotic resistance by targeting cryptic pocketsYangyang Gao0Huimin Chen1Weicheng Yang2Shuang Wang3Daohong Gong4Xiao Zhang5Yuanqin Huang6Vinit Kumar7Qiuqian Huang8W.M.W.W. Kandegama9Gefei Hao10State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR ChinaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China; Department of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, 60170 Sri LankaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China; State Key Laboratory of Green Pesticide, Central China Normal University, Wuhan 430079, PR China; Corresponding author at: State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, PR China.Antibiotic resistance is a global health concern that is rapidly spreading among human and animal pathogens. Developing novel antibiotics is one of the most significant approaches to surmount antibiotic resistance. Given the difficult in identifying novel targets, cryptic binding sites provide new pockets for compounds design to combat antibiotic resistance. However, there exists a lack of comprehensive analysis and discussion on the successful utilization of cryptic pockets in overcoming antibiotic resistance. Here, we systematically analyze the crucial role of cryptic pockets in neutralizing antibiotic resistance. First, antibiotic resistance development and associated resistance mechanisms are summarized. Then, the advantages and mechanisms of cryptic pockets for overcoming antibiotic resistance were discussed. Specific cryptic pockets in resistant proteins and successful case studies of designed inhibitors are exemplified. This review provides insight into the discovery of cryptic pockets for drug design as an approach to overcome antibiotic resistancehttp://www.sciencedirect.com/science/article/pii/S1043661824004407Antibiotic resistanceCryptic pocketNew pocketReducing resistance |
| spellingShingle | Yangyang Gao Huimin Chen Weicheng Yang Shuang Wang Daohong Gong Xiao Zhang Yuanqin Huang Vinit Kumar Qiuqian Huang W.M.W.W. Kandegama Gefei Hao New avenues of combating antibiotic resistance by targeting cryptic pockets Pharmacological Research Antibiotic resistance Cryptic pocket New pocket Reducing resistance |
| title | New avenues of combating antibiotic resistance by targeting cryptic pockets |
| title_full | New avenues of combating antibiotic resistance by targeting cryptic pockets |
| title_fullStr | New avenues of combating antibiotic resistance by targeting cryptic pockets |
| title_full_unstemmed | New avenues of combating antibiotic resistance by targeting cryptic pockets |
| title_short | New avenues of combating antibiotic resistance by targeting cryptic pockets |
| title_sort | new avenues of combating antibiotic resistance by targeting cryptic pockets |
| topic | Antibiotic resistance Cryptic pocket New pocket Reducing resistance |
| url | http://www.sciencedirect.com/science/article/pii/S1043661824004407 |
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