Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the mediu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519400061X |
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| _version_ | 1849467849914974208 |
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| author | Hajime Inoue Nagaoki Wakisaka Nobuhiro Tane Kazumasa Ando Emiko Isono Miwa Yamanaka Masaki Aihara Hirotomo Ishida |
| author_facet | Hajime Inoue Nagaoki Wakisaka Nobuhiro Tane Kazumasa Ando Emiko Isono Miwa Yamanaka Masaki Aihara Hirotomo Ishida |
| author_sort | Hajime Inoue |
| collection | DOAJ |
| description | The possibility that cultured keratinocytes produce
endothelins were investigated. The results showed that
cultured keratinocytes derived from normal human
skin produce endothelin-1. Moreover, keratinocyte
endothelin-1 production was completely inhibited by the
presence of actinomycin D in the medium. As in the case
of endothelial cells, recombinant interleukin-1β was
capable of promoting endothelin-1 production in
keratinocytes, whereas herapin inhibited it. Thrombin
also inhibited endothelin-1 production. These results indicate
that the mechanism of endothelin-1 production in
keratinocytes is slightly different from the mechanism in
vascular endothelial cells. |
| format | Article |
| id | doaj-art-e090fd0bd13646449455bac3494cfa89 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e090fd0bd13646449455bac3494cfa892025-08-20T03:26:00ZengWileyMediators of Inflammation0962-93511466-18611994-01-013643343710.1155/S096293519400061XEndothelin-1 Production by Normal Human Cultured Keratinocytes and its RegulationHajime Inoue0Nagaoki Wakisaka1Nobuhiro Tane2Kazumasa Ando3Emiko Isono4Miwa Yamanaka5Masaki Aihara6Hirotomo Ishida7Department of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanDepartment of Plastic and Reconstructive Surgery, St Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki 216, JapanThe possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the medium. As in the case of endothelial cells, recombinant interleukin-1β was capable of promoting endothelin-1 production in keratinocytes, whereas herapin inhibited it. Thrombin also inhibited endothelin-1 production. These results indicate that the mechanism of endothelin-1 production in keratinocytes is slightly different from the mechanism in vascular endothelial cells.http://dx.doi.org/10.1155/S096293519400061X |
| spellingShingle | Hajime Inoue Nagaoki Wakisaka Nobuhiro Tane Kazumasa Ando Emiko Isono Miwa Yamanaka Masaki Aihara Hirotomo Ishida Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation Mediators of Inflammation |
| title | Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation |
| title_full | Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation |
| title_fullStr | Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation |
| title_full_unstemmed | Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation |
| title_short | Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation |
| title_sort | endothelin 1 production by normal human cultured keratinocytes and its regulation |
| url | http://dx.doi.org/10.1155/S096293519400061X |
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