Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the mediu...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519400061X |
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| Summary: | The possibility that cultured keratinocytes produce
endothelins were investigated. The results showed that
cultured keratinocytes derived from normal human
skin produce endothelin-1. Moreover, keratinocyte
endothelin-1 production was completely inhibited by the
presence of actinomycin D in the medium. As in the case
of endothelial cells, recombinant interleukin-1β was
capable of promoting endothelin-1 production in
keratinocytes, whereas herapin inhibited it. Thrombin
also inhibited endothelin-1 production. These results indicate
that the mechanism of endothelin-1 production in
keratinocytes is slightly different from the mechanism in
vascular endothelial cells. |
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| ISSN: | 0962-9351 1466-1861 |