Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush

Adenosine A2A receptor activation is necessary to gate the TrkB-dependent intramuscular nerve sprouting during muscle reinnervation after a nerve crush

Compelling evidence has demonstrated that rehabilitation through physical exercise, a non-invasive and non-surgical intervention, enhances muscle reinnervation and motor recovery after peripheral nerve injury (PNI) by increasing muscle-derived brain-derived neurotrophic factor (BDNF) expression and...

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Bibliographic Details
Main Authors: Michael Di Palma, Davide Lattanzi, Patrizia Ambrogini, Stefano Sartini
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Peripheral nerve lesion
Exercise
Terminal axon sprouting
Muscle reinnervation
Tropomyosin-related kinase B receptor
Adenosine A2A receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024174725
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