Circadian immune system in solid organ transplantation: a review article
The innate and adaptive immune systems are intricately regulated by the circadian clock machinery. Recent clinical investigations have shed light on the influence of timing in organ procurement and transplantation on graft survival. In this review, we explore various mechanisms of immunological func...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556057/full |
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| author | Wai Yen Yim Chenghao Li Fuqiang Tong Jincheng Hou Yuqi Chen Zongtao Liu Zihao Wang Bingchuan Geng Yixuan Wang Yixuan Wang Nianguo Dong Nianguo Dong |
| author_facet | Wai Yen Yim Chenghao Li Fuqiang Tong Jincheng Hou Yuqi Chen Zongtao Liu Zihao Wang Bingchuan Geng Yixuan Wang Yixuan Wang Nianguo Dong Nianguo Dong |
| author_sort | Wai Yen Yim |
| collection | DOAJ |
| description | The innate and adaptive immune systems are intricately regulated by the circadian clock machinery. Recent clinical investigations have shed light on the influence of timing in organ procurement and transplantation on graft survival. In this review, we explore various mechanisms of immunological functions associated with the steps involved in organ transplantation, spanning from surgical harvesting to reperfusion and linking to the circadian rhythm. A deeper understanding of these processes has the potential to extend the principles of chrono-immunotherapy to the realm of organ transplantation, with the aim of enhancing graft durability and improving patient outcomes. This review concludes with some perspectives on future directions in this exciting and still evolving field of research. |
| format | Article |
| id | doaj-art-e08eb9d419184ae085b2249b0758f6eb |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e08eb9d419184ae085b2249b0758f6eb2025-08-20T03:00:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15560571556057Circadian immune system in solid organ transplantation: a review articleWai Yen Yim0Chenghao Li1Fuqiang Tong2Jincheng Hou3Yuqi Chen4Zongtao Liu5Zihao Wang6Bingchuan Geng7Yixuan Wang8Yixuan Wang9Nianguo Dong10Nianguo Dong11Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaKey Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, ChinaThe innate and adaptive immune systems are intricately regulated by the circadian clock machinery. Recent clinical investigations have shed light on the influence of timing in organ procurement and transplantation on graft survival. In this review, we explore various mechanisms of immunological functions associated with the steps involved in organ transplantation, spanning from surgical harvesting to reperfusion and linking to the circadian rhythm. A deeper understanding of these processes has the potential to extend the principles of chrono-immunotherapy to the realm of organ transplantation, with the aim of enhancing graft durability and improving patient outcomes. This review concludes with some perspectives on future directions in this exciting and still evolving field of research.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556057/fullcircadian rhythmchronotherapytransplantationtransplant immunologyantigen presentationtime-of-day |
| spellingShingle | Wai Yen Yim Chenghao Li Fuqiang Tong Jincheng Hou Yuqi Chen Zongtao Liu Zihao Wang Bingchuan Geng Yixuan Wang Yixuan Wang Nianguo Dong Nianguo Dong Circadian immune system in solid organ transplantation: a review article Frontiers in Immunology circadian rhythm chronotherapy transplantation transplant immunology antigen presentation time-of-day |
| title | Circadian immune system in solid organ transplantation: a review article |
| title_full | Circadian immune system in solid organ transplantation: a review article |
| title_fullStr | Circadian immune system in solid organ transplantation: a review article |
| title_full_unstemmed | Circadian immune system in solid organ transplantation: a review article |
| title_short | Circadian immune system in solid organ transplantation: a review article |
| title_sort | circadian immune system in solid organ transplantation a review article |
| topic | circadian rhythm chronotherapy transplantation transplant immunology antigen presentation time-of-day |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1556057/full |
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