NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans

NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans

IntroductionGenetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHTN). We set out to evaluate the contribution of genetic variati...

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Bibliographic Details
Main Authors: Jonathan N. Katsukunya, Revina Naicker, Nyarai D. Soko, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Brian Rayner, Erika Jones, Collet Dandara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
Subjects:
CES1
NOS3
pharmacogenomics
hypertension
Africans
ACE inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1608423/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1608423/full

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