Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung
Numerous modern neuropsychotropic drugs used in medical practice affect neurohumoral transmission in monoaminergic neuronal systems. Some important sites of action of these drugs can be summarized as follows: Transmitter synthesis L-Dopa Decarboxylase inhibitors Transmitter storage: granular...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
1978-04-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9404 |
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| _version_ | 1849697947563851776 |
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| author | Alfred Pletscher |
| author_facet | Alfred Pletscher |
| author_sort | Alfred Pletscher |
| collection | DOAJ |
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Numerous modern neuropsychotropic drugs used in medical practice affect neurohumoral transmission in monoaminergic neuronal systems. Some important sites of action of these drugs can be summarized as follows:
Transmitter synthesis
L-Dopa
Decarboxylase inhibitors
Transmitter storage:
granular membrane
intragranular storage
extragranular storage
Reserpine and related drugs
Phenyl- and indolylalkylamines
False neurotransmitters
Amantadine ? Amphetamine ?
Re-uptake at cytoplasmatic membrane
Tricyclic antidepressants
Inactivating enzymes
Monoamine oxidase inhibitors
Dopamine receptors
Agonists: Apomorphine
Ergoline derivatives
Antagonists: Neuroleptics
The consecutive changes in neurohumoral transmission are probably at least partly responsible for the therapeutic action of the above mentioned drugs. An effect on steps of monoaminergic transmission other than that quoted above as well as influences on other transmitter systems, e. g. those containing acetylcholine or γ-aminobutyric acid (GABA), may also be of importance in determining the clinical profile of the drugs mentioned above. Substances acting mainly on non-monoaminergic systems include the benzodiazepines (selective enhancement of GABA action) and probably muscle relaxants such as baclofen. The discovery of neuronal systems containing polypeptides as possible neurotransmitters or neuromodulators opens new possibilities in the search for neuropsychotropic drugs.
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| format | Article |
| id | doaj-art-e08c8214438b42458d6c08b140e6ed96 |
| institution | DOAJ |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 1978-04-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-e08c8214438b42458d6c08b140e6ed962025-08-20T03:19:03ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241978-04-0132410.2533/chimia.1978.113Wirkung von Neuropsychopharmaka auf die neurohumorale ÜbertragungAlfred Pletscher0F. Hoffmann-La Roche & Co. AG, Basel Numerous modern neuropsychotropic drugs used in medical practice affect neurohumoral transmission in monoaminergic neuronal systems. Some important sites of action of these drugs can be summarized as follows: Transmitter synthesis L-Dopa Decarboxylase inhibitors Transmitter storage: granular membrane intragranular storage extragranular storage Reserpine and related drugs Phenyl- and indolylalkylamines False neurotransmitters Amantadine ? Amphetamine ? Re-uptake at cytoplasmatic membrane Tricyclic antidepressants Inactivating enzymes Monoamine oxidase inhibitors Dopamine receptors Agonists: Apomorphine Ergoline derivatives Antagonists: Neuroleptics The consecutive changes in neurohumoral transmission are probably at least partly responsible for the therapeutic action of the above mentioned drugs. An effect on steps of monoaminergic transmission other than that quoted above as well as influences on other transmitter systems, e. g. those containing acetylcholine or γ-aminobutyric acid (GABA), may also be of importance in determining the clinical profile of the drugs mentioned above. Substances acting mainly on non-monoaminergic systems include the benzodiazepines (selective enhancement of GABA action) and probably muscle relaxants such as baclofen. The discovery of neuronal systems containing polypeptides as possible neurotransmitters or neuromodulators opens new possibilities in the search for neuropsychotropic drugs. https://www.chimia.ch/chimia/article/view/9404 |
| spellingShingle | Alfred Pletscher Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung CHIMIA |
| title | Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung |
| title_full | Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung |
| title_fullStr | Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung |
| title_full_unstemmed | Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung |
| title_short | Wirkung von Neuropsychopharmaka auf die neurohumorale Übertragung |
| title_sort | wirkung von neuropsychopharmaka auf die neurohumorale ubertragung |
| url | https://www.chimia.ch/chimia/article/view/9404 |
| work_keys_str_mv | AT alfredpletscher wirkungvonneuropsychopharmakaaufdieneurohumoraleubertragung |