The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders
The human gut microbiota is a complex ecosystem made of trillions of microorganisms. The composition can be affected by diet, metabolism, age, geography, stress, seasons, temperature, sleep, and medications. The increasing evidence about the existence of a close and bi-directional correlation betwee...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Revinter Publicações
2023-07-01
|
| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767818 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849761219029762048 |
|---|---|
| author | Maria Fernanda Naufel Giselle de Martin Truzzi Caroline Marcantonio Ferreira Fernando Morgadinho Santos Coelho |
| author_facet | Maria Fernanda Naufel Giselle de Martin Truzzi Caroline Marcantonio Ferreira Fernando Morgadinho Santos Coelho |
| author_sort | Maria Fernanda Naufel |
| collection | DOAJ |
| description | The human gut microbiota is a complex ecosystem made of trillions of microorganisms. The composition can be affected by diet, metabolism, age, geography, stress, seasons, temperature, sleep, and medications. The increasing evidence about the existence of a close and bi-directional correlation between the gut microbiota and the brain indicates that intestinal imbalance may play a vital role in the development, function, and disorders of the central nervous system. The mechanisms of interaction between the gut-microbiota on neuronal activity are widely discussed. Several potential pathways are involved with the brain-gut-microbiota axis, including the vagus nerve, endocrine, immune, and biochemical pathways. Gut dysbiosis has been linked to neurological disorders in different ways that involve activation of the hypothalamic-pituitary-adrenal axis, imbalance in neurotransmitter release, systemic inflammation, and increase in the permeability of the intestinal and the blood-brain barrier. Mental and neurological diseases have become more prevalent during the coronavirus disease 2019pandemic and are an essential issue in public health globally. Understanding the importance of diagnosing, preventing, and treating dysbiosis is critical because gut microbial imbalance is a significant risk factor for these disorders. This review summarizes evidence demonstrating the influence of gut dysbiosis on mental and neurological disorders. |
| format | Article |
| id | doaj-art-e08b9acac76046fa8795697ef89f17f4 |
| institution | DOAJ |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e08b9acac76046fa8795697ef89f17f42025-08-20T03:06:06ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272023-07-01810767068410.1055/s-0043-1767818The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disordersMaria Fernanda Naufel0https://orcid.org/0000-0001-8773-811XGiselle de Martin Truzzi1https://orcid.org/0000-0002-2051-8259Caroline Marcantonio Ferreira2https://orcid.org/0000-0003-3484-2081Fernando Morgadinho Santos Coelho3https://orcid.org/0000-0002-8482-3754Universidade Federal de São Paulo, Departamento de Fisiologia, São Paulo SP, Brazil.Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo SP, Brazil.Universidade Federal de São Paulo, Departamento de Ciências Farmacêuticas, São Paulo SP, Brazil.Universidade Federal de São Paulo, Departamento de Psicobiologia, São Paulo SP, Brazil.The human gut microbiota is a complex ecosystem made of trillions of microorganisms. The composition can be affected by diet, metabolism, age, geography, stress, seasons, temperature, sleep, and medications. The increasing evidence about the existence of a close and bi-directional correlation between the gut microbiota and the brain indicates that intestinal imbalance may play a vital role in the development, function, and disorders of the central nervous system. The mechanisms of interaction between the gut-microbiota on neuronal activity are widely discussed. Several potential pathways are involved with the brain-gut-microbiota axis, including the vagus nerve, endocrine, immune, and biochemical pathways. Gut dysbiosis has been linked to neurological disorders in different ways that involve activation of the hypothalamic-pituitary-adrenal axis, imbalance in neurotransmitter release, systemic inflammation, and increase in the permeability of the intestinal and the blood-brain barrier. Mental and neurological diseases have become more prevalent during the coronavirus disease 2019pandemic and are an essential issue in public health globally. Understanding the importance of diagnosing, preventing, and treating dysbiosis is critical because gut microbial imbalance is a significant risk factor for these disorders. This review summarizes evidence demonstrating the influence of gut dysbiosis on mental and neurological disorders.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767818Gastrointestinal MicrobiomeDysbiosisCentral Nervous SystemTherapeuticsMicrobioma GastrointestinalDisbioseSistema Nervoso CentralTerapêutica |
| spellingShingle | Maria Fernanda Naufel Giselle de Martin Truzzi Caroline Marcantonio Ferreira Fernando Morgadinho Santos Coelho The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders Arquivos de Neuro-Psiquiatria Gastrointestinal Microbiome Dysbiosis Central Nervous System Therapeutics Microbioma Gastrointestinal Disbiose Sistema Nervoso Central Terapêutica |
| title | The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders |
| title_full | The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders |
| title_fullStr | The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders |
| title_full_unstemmed | The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders |
| title_short | The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders |
| title_sort | brain gut microbiota axis in the treatment of neurologic and psychiatric disorders |
| topic | Gastrointestinal Microbiome Dysbiosis Central Nervous System Therapeutics Microbioma Gastrointestinal Disbiose Sistema Nervoso Central Terapêutica |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1767818 |
| work_keys_str_mv | AT mariafernandanaufel thebraingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT giselledemartintruzzi thebraingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT carolinemarcantonioferreira thebraingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT fernandomorgadinhosantoscoelho thebraingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT mariafernandanaufel braingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT giselledemartintruzzi braingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT carolinemarcantonioferreira braingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders AT fernandomorgadinhosantoscoelho braingutmicrobiotaaxisinthetreatmentofneurologicandpsychiatricdisorders |