Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication.
Studies show evidence of longitudinal brain volume decreases in schizophrenia. We studied brain volume changes and their relation to symptom severity, level of function, cognition, and antipsychotic medication in participants with schizophrenia and control participants from a general population base...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0101689 |
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| author | Juha Veijola Joyce Y Guo Jani S Moilanen Erika Jääskeläinen Jouko Miettunen Merja Kyllönen Marianne Haapea Sanna Huhtaniska Antti Alaräisänen Pirjo Mäki Vesa Kiviniemi Juha Nikkinen Tuomo Starck Jukka J Remes Päivikki Tanskanen Osmo Tervonen Alle-Meije Wink Angie Kehagia John Suckling Hiroyuki Kobayashi Jennifer H Barnett Anna Barnes Hannu J Koponen Peter B Jones Matti Isohanni Graham K Murray |
| author_facet | Juha Veijola Joyce Y Guo Jani S Moilanen Erika Jääskeläinen Jouko Miettunen Merja Kyllönen Marianne Haapea Sanna Huhtaniska Antti Alaräisänen Pirjo Mäki Vesa Kiviniemi Juha Nikkinen Tuomo Starck Jukka J Remes Päivikki Tanskanen Osmo Tervonen Alle-Meije Wink Angie Kehagia John Suckling Hiroyuki Kobayashi Jennifer H Barnett Anna Barnes Hannu J Koponen Peter B Jones Matti Isohanni Graham K Murray |
| author_sort | Juha Veijola |
| collection | DOAJ |
| description | Studies show evidence of longitudinal brain volume decreases in schizophrenia. We studied brain volume changes and their relation to symptom severity, level of function, cognition, and antipsychotic medication in participants with schizophrenia and control participants from a general population based birth cohort sample in a relatively long follow-up period of almost a decade. All members of the Northern Finland Birth Cohort 1966 with any psychotic disorder and a random sample not having psychosis were invited for a MRI brain scan, and clinical and cognitive assessment during 1999-2001 at the age of 33-35 years. A follow-up was conducted 9 years later during 2008-2010. Brain scans at both time points were obtained from 33 participants with schizophrenia and 71 control participants. Regression models were used to examine whether brain volume changes predicted clinical and cognitive changes over time, and whether antipsychotic medication predicted brain volume changes. The mean annual whole brain volume reduction was 0.69% in schizophrenia, and 0.49% in controls (p = 0.003, adjusted for gender, educational level, alcohol use and weight gain). The brain volume reduction in schizophrenia patients was found especially in the temporal lobe and periventricular area. Symptom severity, functioning level, and decline in cognition were not associated with brain volume reduction in schizophrenia. The amount of antipsychotic medication (dose years of equivalent to 100 mg daily chlorpromazine) over the follow-up period predicted brain volume loss (p = 0.003 adjusted for symptom level, alcohol use and weight gain). In this population based sample, brain volume reduction continues in schizophrenia patients after the onset of illness, and antipsychotic medications may contribute to these reductions. |
| format | Article |
| id | doaj-art-e084cdcd0c3c49e4a829be5b5b4c6ba8 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e084cdcd0c3c49e4a829be5b5b4c6ba82025-08-20T02:22:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10168910.1371/journal.pone.0101689Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication.Juha VeijolaJoyce Y GuoJani S MoilanenErika JääskeläinenJouko MiettunenMerja KyllönenMarianne HaapeaSanna HuhtaniskaAntti AlaräisänenPirjo MäkiVesa KiviniemiJuha NikkinenTuomo StarckJukka J RemesPäivikki TanskanenOsmo TervonenAlle-Meije WinkAngie KehagiaJohn SucklingHiroyuki KobayashiJennifer H BarnettAnna BarnesHannu J KoponenPeter B JonesMatti IsohanniGraham K MurrayStudies show evidence of longitudinal brain volume decreases in schizophrenia. We studied brain volume changes and their relation to symptom severity, level of function, cognition, and antipsychotic medication in participants with schizophrenia and control participants from a general population based birth cohort sample in a relatively long follow-up period of almost a decade. All members of the Northern Finland Birth Cohort 1966 with any psychotic disorder and a random sample not having psychosis were invited for a MRI brain scan, and clinical and cognitive assessment during 1999-2001 at the age of 33-35 years. A follow-up was conducted 9 years later during 2008-2010. Brain scans at both time points were obtained from 33 participants with schizophrenia and 71 control participants. Regression models were used to examine whether brain volume changes predicted clinical and cognitive changes over time, and whether antipsychotic medication predicted brain volume changes. The mean annual whole brain volume reduction was 0.69% in schizophrenia, and 0.49% in controls (p = 0.003, adjusted for gender, educational level, alcohol use and weight gain). The brain volume reduction in schizophrenia patients was found especially in the temporal lobe and periventricular area. Symptom severity, functioning level, and decline in cognition were not associated with brain volume reduction in schizophrenia. The amount of antipsychotic medication (dose years of equivalent to 100 mg daily chlorpromazine) over the follow-up period predicted brain volume loss (p = 0.003 adjusted for symptom level, alcohol use and weight gain). In this population based sample, brain volume reduction continues in schizophrenia patients after the onset of illness, and antipsychotic medications may contribute to these reductions.https://doi.org/10.1371/journal.pone.0101689 |
| spellingShingle | Juha Veijola Joyce Y Guo Jani S Moilanen Erika Jääskeläinen Jouko Miettunen Merja Kyllönen Marianne Haapea Sanna Huhtaniska Antti Alaräisänen Pirjo Mäki Vesa Kiviniemi Juha Nikkinen Tuomo Starck Jukka J Remes Päivikki Tanskanen Osmo Tervonen Alle-Meije Wink Angie Kehagia John Suckling Hiroyuki Kobayashi Jennifer H Barnett Anna Barnes Hannu J Koponen Peter B Jones Matti Isohanni Graham K Murray Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. PLoS ONE |
| title | Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. |
| title_full | Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. |
| title_fullStr | Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. |
| title_full_unstemmed | Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. |
| title_short | Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication. |
| title_sort | longitudinal changes in total brain volume in schizophrenia relation to symptom severity cognition and antipsychotic medication |
| url | https://doi.org/10.1371/journal.pone.0101689 |
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