Human brain organoids: an innovative model for neurological disorder research and therapy
The emergence of human brain organoids (hBOs) has transformed how we study brain development, disease mechanisms, and therapy discovery. These 3D in vitro neural models closely mimic the cellular diversity, spatial structure, and functional connectivity of the human brain, providing a groundbreaking...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2025.1658074/full |
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| author | Hancheng Li Hancheng Li Junxiao Zhu Junxiao Zhu Jieyu Li Yangkai Wu Chaohua Luo Yuting Huang Jieru Wu Wenhua Liu Hongwu Wang Hongwu Wang Zhixian Mo |
| author_facet | Hancheng Li Hancheng Li Junxiao Zhu Junxiao Zhu Jieyu Li Yangkai Wu Chaohua Luo Yuting Huang Jieru Wu Wenhua Liu Hongwu Wang Hongwu Wang Zhixian Mo |
| author_sort | Hancheng Li |
| collection | DOAJ |
| description | The emergence of human brain organoids (hBOs) has transformed how we study brain development, disease mechanisms, and therapy discovery. These 3D in vitro neural models closely mimic the cellular diversity, spatial structure, and functional connectivity of the human brain, providing a groundbreaking platform that outperforms traditional 2D cultures and animal models in studying neurodevelopment and neurological disorders. To further explore the potential of hBOs technology, we review current literature focusing particularly on its applications for diagnosing and treating major neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and other related neurological disorders. Using patient-derived induced pluripotent stem cells combined with cutting-edge gene-editing technologies, hBOs enable highly precise mechanistic studies and scalable drug screening. Moreover, we further discuss the advantages and current limitations of hBOs. Despite these challenges, hBOs remain a transformative platform for the development of targeted neurotherapeutics. Collectively, this review offers a solid foundation for advancing neuroscience research and fostering innovative treatment strategies for neurological disorders. |
| format | Article |
| id | doaj-art-e0812da7f60247078aafef0f681c6891 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-e0812da7f60247078aafef0f681c68912025-08-26T05:28:09ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-08-011910.3389/fncel.2025.16580741658074Human brain organoids: an innovative model for neurological disorder research and therapyHancheng Li0Hancheng Li1Junxiao Zhu2Junxiao Zhu3Jieyu Li4Yangkai Wu5Chaohua Luo6Yuting Huang7Jieru Wu8Wenhua Liu9Hongwu Wang10Hongwu Wang11Zhixian Mo12Department of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmacology of Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaKey Laboratory for Research and Utilization of Southern Medicine, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmacology of Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaKey Laboratory for Research and Utilization of Southern Medicine, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmaceutical Engineering, School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, ChinaRisk Assessment Laboratory for Agricultural Product Quality and Safety, Ministry of Agriculture and Rural Development, Zhaoqing University, Zhaoqing, ChinaDepartment of Pharmacology of Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, ChinaThe emergence of human brain organoids (hBOs) has transformed how we study brain development, disease mechanisms, and therapy discovery. These 3D in vitro neural models closely mimic the cellular diversity, spatial structure, and functional connectivity of the human brain, providing a groundbreaking platform that outperforms traditional 2D cultures and animal models in studying neurodevelopment and neurological disorders. To further explore the potential of hBOs technology, we review current literature focusing particularly on its applications for diagnosing and treating major neurological diseases such as Alzheimer’s disease, Parkinson’s disease, and other related neurological disorders. Using patient-derived induced pluripotent stem cells combined with cutting-edge gene-editing technologies, hBOs enable highly precise mechanistic studies and scalable drug screening. Moreover, we further discuss the advantages and current limitations of hBOs. Despite these challenges, hBOs remain a transformative platform for the development of targeted neurotherapeutics. Collectively, this review offers a solid foundation for advancing neuroscience research and fostering innovative treatment strategies for neurological disorders.https://www.frontiersin.org/articles/10.3389/fncel.2025.1658074/fullhuman brain organoidsneurological disordersdisease modelingtherapeutic innovationinduced pluripotent stem cells |
| spellingShingle | Hancheng Li Hancheng Li Junxiao Zhu Junxiao Zhu Jieyu Li Yangkai Wu Chaohua Luo Yuting Huang Jieru Wu Wenhua Liu Hongwu Wang Hongwu Wang Zhixian Mo Human brain organoids: an innovative model for neurological disorder research and therapy Frontiers in Cellular Neuroscience human brain organoids neurological disorders disease modeling therapeutic innovation induced pluripotent stem cells |
| title | Human brain organoids: an innovative model for neurological disorder research and therapy |
| title_full | Human brain organoids: an innovative model for neurological disorder research and therapy |
| title_fullStr | Human brain organoids: an innovative model for neurological disorder research and therapy |
| title_full_unstemmed | Human brain organoids: an innovative model for neurological disorder research and therapy |
| title_short | Human brain organoids: an innovative model for neurological disorder research and therapy |
| title_sort | human brain organoids an innovative model for neurological disorder research and therapy |
| topic | human brain organoids neurological disorders disease modeling therapeutic innovation induced pluripotent stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2025.1658074/full |
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