Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost

Safety and immunogenicity of an HIV vaccine trial with DNA prime and replicating vaccinia boost

Abstract Developing a safe and effective vaccine remains a global priority for ending the human immunodeficiency virus (HIV) pandemic. All HIV vaccine trials with protein, DNA, non-replication vector or their combinations failed in the past. We constructed the HIV-1 CN54 env, gag, and pol genes into...

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Main Authors: Ying Liu, Wei Lv, Pu Shan, Dan Li, Ying-Qi Wu, You-Chun Wang, Yuan-Yuan Li, Qiang Liu, Jian-Sheng Wang, Yan-Ling Hao, Yong Liu, Wei-Jin Huang, Li Ren, Shu-Hui Wang, Tai-Sheng Li, Jing Xu, Yi-Ming Shao
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02259-y
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