Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty fish and plant-based sources. Compelling evidence from preclinical and epide...
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MDPI AG
2024-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/10/446 |
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| author | Zayana Ali Mohammad Ahmed Al-Ghouti Haissam Abou-Saleh Md Mizanur Rahman |
| author_facet | Zayana Ali Mohammad Ahmed Al-Ghouti Haissam Abou-Saleh Md Mizanur Rahman |
| author_sort | Zayana Ali |
| collection | DOAJ |
| description | Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty fish and plant-based sources. Compelling evidence from preclinical and epidemiological studies consistently suggests beneficial effects of ω-3 PUFAs on bone health and healthy aging processes. However, clinical trials have yielded mixed results, with some failing to replicate these benefits seen in preclinical models. This contraindication is mainly due to challenges such as low bioavailability, potential adverse effects with higher doses, and susceptibility to oxidation of ω-3 fatty acids, hindering their clinical effectiveness. This review comprehensively discusses recent findings from a clinical perspective, along with preclinical and epidemiological studies, emphasizing the role of ω-3 PUFAs in promoting bone health and supporting healthy aging. Additionally, it explores strategies to improve ω-3 PUFA efficacy, including nanoparticle encapsulation and incorporation of specialized pro-resolving mediators (SPM) derived from DHA and EPA, to mitigate oxidation and enhance solubility, thereby improving therapeutic potential. By consolidating evidence from various studies, this review underscores current insights and future directions in leveraging ω-3 PUFAs for therapeutic applications. |
| format | Article |
| id | doaj-art-e0809092f79f403f9a3a548dfdf0470c |
| institution | OA Journals |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-e0809092f79f403f9a3a548dfdf0470c2025-08-20T02:10:56ZengMDPI AGMarine Drugs1660-33972024-09-01221044610.3390/md22100446Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy AgingZayana Ali0Mohammad Ahmed Al-Ghouti1Haissam Abou-Saleh2Md Mizanur Rahman3Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarEnvironmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarBiomedical Sciences Department, College of Health Sciences, Qatar University, Doha P.O. Box 2713, QatarBiological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, QatarOmega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty fish and plant-based sources. Compelling evidence from preclinical and epidemiological studies consistently suggests beneficial effects of ω-3 PUFAs on bone health and healthy aging processes. However, clinical trials have yielded mixed results, with some failing to replicate these benefits seen in preclinical models. This contraindication is mainly due to challenges such as low bioavailability, potential adverse effects with higher doses, and susceptibility to oxidation of ω-3 fatty acids, hindering their clinical effectiveness. This review comprehensively discusses recent findings from a clinical perspective, along with preclinical and epidemiological studies, emphasizing the role of ω-3 PUFAs in promoting bone health and supporting healthy aging. Additionally, it explores strategies to improve ω-3 PUFA efficacy, including nanoparticle encapsulation and incorporation of specialized pro-resolving mediators (SPM) derived from DHA and EPA, to mitigate oxidation and enhance solubility, thereby improving therapeutic potential. By consolidating evidence from various studies, this review underscores current insights and future directions in leveraging ω-3 PUFAs for therapeutic applications.https://www.mdpi.com/1660-3397/22/10/446omega-3 polyunsaturated fatty acidseicosapentaenoic acid (EPA)docosahexaenoic acid (DHA)bone healthagingbioavailability |
| spellingShingle | Zayana Ali Mohammad Ahmed Al-Ghouti Haissam Abou-Saleh Md Mizanur Rahman Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging Marine Drugs omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) bone health aging bioavailability |
| title | Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging |
| title_full | Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging |
| title_fullStr | Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging |
| title_full_unstemmed | Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging |
| title_short | Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging |
| title_sort | unraveling the omega 3 puzzle navigating challenges and innovations for bone health and healthy aging |
| topic | omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) bone health aging bioavailability |
| url | https://www.mdpi.com/1660-3397/22/10/446 |
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