CD32a polymorphism rs1801274 affects the risk of Kawasaki disease
Aim To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence interval...
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2019.1645156 |
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| author | Zhiyong Wang Pei-Liang Geng |
| author_facet | Zhiyong Wang Pei-Liang Geng |
| author_sort | Zhiyong Wang |
| collection | DOAJ |
| description | Aim To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented on the basis of ethnicity and control source, respectively. Between-study heterogeneity was checked adopting chi-square-based Q test, with p < .05 as significant level. And results from Q test determined which model would be employed for OR calculation, fixed- or random-effects. Sensitivity analysis was accomplished to test the stability of final results. Potential publication bias among included studies was investigated using Begg’s funnel plot and Egger’s test. If publication bias was significant, its influence on overall estimates would be measured adopting the trim-and-fill method.Results CD32a polymorphism rs1801274 significantly increased KD risk in total analysis under the comparisons of AA vs. GG, AA + AG vs. GG, AA vs. GG + AG, A vs. G and AG vs. GG (OR = 2.69, 95% CI = 1.39–5.20; OR = 2.00, 95% CI = 1.23–3.26; OR = 1.90, 95% CI = 1.23–2.94; OR = 1.77, 95% CI = 1.34–2.34; OR = 1.53, 95% CI = 1.07–2.19). After stratification analysis by ethnicity, similar tendency was also observed in Caucasian and Asian subgroups under corresponding genetic models. And parallel results were replicated in population-based and other-source subgroups after stratified analysis by control source, under some contrasts.Conclusion CD32a polymorphism rs1801274 has strong relation to KD onset, and the presence of its A allele could elevate the disease incidence. |
| format | Article |
| id | doaj-art-e07aa43aacf64ec9aed84a6d28efa532 |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-e07aa43aacf64ec9aed84a6d28efa5322025-08-20T03:41:25ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-0148162062610.1080/21691401.2019.1645156CD32a polymorphism rs1801274 affects the risk of Kawasaki diseaseZhiyong Wang0Pei-Liang Geng1Department of Pediatrics, Weifang Maternal and Child Health Hospital, Weifang, ChinaCenter for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, ChinaAim To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented on the basis of ethnicity and control source, respectively. Between-study heterogeneity was checked adopting chi-square-based Q test, with p < .05 as significant level. And results from Q test determined which model would be employed for OR calculation, fixed- or random-effects. Sensitivity analysis was accomplished to test the stability of final results. Potential publication bias among included studies was investigated using Begg’s funnel plot and Egger’s test. If publication bias was significant, its influence on overall estimates would be measured adopting the trim-and-fill method.Results CD32a polymorphism rs1801274 significantly increased KD risk in total analysis under the comparisons of AA vs. GG, AA + AG vs. GG, AA vs. GG + AG, A vs. G and AG vs. GG (OR = 2.69, 95% CI = 1.39–5.20; OR = 2.00, 95% CI = 1.23–3.26; OR = 1.90, 95% CI = 1.23–2.94; OR = 1.77, 95% CI = 1.34–2.34; OR = 1.53, 95% CI = 1.07–2.19). After stratification analysis by ethnicity, similar tendency was also observed in Caucasian and Asian subgroups under corresponding genetic models. And parallel results were replicated in population-based and other-source subgroups after stratified analysis by control source, under some contrasts.Conclusion CD32a polymorphism rs1801274 has strong relation to KD onset, and the presence of its A allele could elevate the disease incidence.https://www.tandfonline.com/doi/10.1080/21691401.2019.1645156Kawasaki diseaseFcγ receptorFcγRIIACD32apolymorphism |
| spellingShingle | Zhiyong Wang Pei-Liang Geng CD32a polymorphism rs1801274 affects the risk of Kawasaki disease Artificial Cells, Nanomedicine, and Biotechnology Kawasaki disease Fcγ receptor FcγRIIA CD32a polymorphism |
| title | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease |
| title_full | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease |
| title_fullStr | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease |
| title_full_unstemmed | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease |
| title_short | CD32a polymorphism rs1801274 affects the risk of Kawasaki disease |
| title_sort | cd32a polymorphism rs1801274 affects the risk of kawasaki disease |
| topic | Kawasaki disease Fcγ receptor FcγRIIA CD32a polymorphism |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2019.1645156 |
| work_keys_str_mv | AT zhiyongwang cd32apolymorphismrs1801274affectstheriskofkawasakidisease AT peilianggeng cd32apolymorphismrs1801274affectstheriskofkawasakidisease |