Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions
Neuromodulation has profoundly transformed medical science, offering new treatments for various neurological conditions. Stimulation techniques that target the brain, spinal cord, trigeminal nerve, and vagus nerve (VN) use electrical impulses to modulate neural functions. Among these, vagus nerve st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1609654/full |
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| author | Birendra Sharma Birendra Sharma Krysten A. Jones Krysten A. Jones Robert M. Lober Candice N. Hatcher-Solis |
| author_facet | Birendra Sharma Birendra Sharma Krysten A. Jones Krysten A. Jones Robert M. Lober Candice N. Hatcher-Solis |
| author_sort | Birendra Sharma |
| collection | DOAJ |
| description | Neuromodulation has profoundly transformed medical science, offering new treatments for various neurological conditions. Stimulation techniques that target the brain, spinal cord, trigeminal nerve, and vagus nerve (VN) use electrical impulses to modulate neural functions. Among these, vagus nerve stimulation (VNS) is distinguished for its use to stimulate the VN to modulate neural functions. VNS shows promising applications across a wide range of neurological conditions, exemplifying the ongoing evolution of neuromodulation. As VNS continues to prove its efficacy, an important consideration in its application arises over the optimal VN stimulation site due to the bilateral nature of the VN. This review highlights the need for comparative studies of left VNS (L-VNS) and right VNS (R-VNS) to enhance our understanding of neurophysiology. The advantages and limitations of stimulation to the left VN or right VN are examined to potentially lead to more personalized and effective treatment strategies. |
| format | Article |
| id | doaj-art-e076aef564754eceae67733a1f7315d7 |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-e076aef564754eceae67733a1f7315d72025-08-20T03:34:57ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-07-011910.3389/fnhum.2025.16096541609654Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directionsBirendra Sharma0Birendra Sharma1Krysten A. Jones2Krysten A. Jones3Robert M. Lober4Candice N. Hatcher-Solis5Cognitive Neuroscience, 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, United StatesOak Ridge Institute for Science and Education, Oak Ridge, TN, United StatesCognitive Neuroscience, 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, United StatesAV, Inc., Dayton, OH, United StatesDepartment of Neurosurgery, Dayton Children's Hospital, Dayton, OH, United StatesCognitive Neuroscience, 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, United StatesNeuromodulation has profoundly transformed medical science, offering new treatments for various neurological conditions. Stimulation techniques that target the brain, spinal cord, trigeminal nerve, and vagus nerve (VN) use electrical impulses to modulate neural functions. Among these, vagus nerve stimulation (VNS) is distinguished for its use to stimulate the VN to modulate neural functions. VNS shows promising applications across a wide range of neurological conditions, exemplifying the ongoing evolution of neuromodulation. As VNS continues to prove its efficacy, an important consideration in its application arises over the optimal VN stimulation site due to the bilateral nature of the VN. This review highlights the need for comparative studies of left VNS (L-VNS) and right VNS (R-VNS) to enhance our understanding of neurophysiology. The advantages and limitations of stimulation to the left VN or right VN are examined to potentially lead to more personalized and effective treatment strategies.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1609654/fullleft VNSright VNSclinical efficacyepilepsycardiac functiondepression |
| spellingShingle | Birendra Sharma Birendra Sharma Krysten A. Jones Krysten A. Jones Robert M. Lober Candice N. Hatcher-Solis Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions Frontiers in Human Neuroscience left VNS right VNS clinical efficacy epilepsy cardiac function depression |
| title | Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions |
| title_full | Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions |
| title_fullStr | Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions |
| title_full_unstemmed | Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions |
| title_short | Left and right vagus nerve stimulation: historical perspectives, clinical efficacy, and future directions |
| title_sort | left and right vagus nerve stimulation historical perspectives clinical efficacy and future directions |
| topic | left VNS right VNS clinical efficacy epilepsy cardiac function depression |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1609654/full |
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