Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial
Abstract Background The concept of vital pulp therapy (VPT) of immature permanent teeth has evolved in recent years. There has been a great tendency towards investigating new pulp capping materials for perfect imitation for natural dentin-pulp complex formation process and restoring the normal tissu...
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| Language: | English |
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BMC
2025-05-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05997-1 |
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| author | Nora M. Abo Shanady Nahed A. Abo Hamila Gamal M. El Maghraby Rehab F. Ghouraba |
| author_facet | Nora M. Abo Shanady Nahed A. Abo Hamila Gamal M. El Maghraby Rehab F. Ghouraba |
| author_sort | Nora M. Abo Shanady |
| collection | DOAJ |
| description | Abstract Background The concept of vital pulp therapy (VPT) of immature permanent teeth has evolved in recent years. There has been a great tendency towards investigating new pulp capping materials for perfect imitation for natural dentin-pulp complex formation process and restoring the normal tissue’s characteristics. Therefore, this study aimed to assess the clinical and tomographic outcomes of apexogenesis with human treated dentin matrix (hTDM) compared to mineral trioxide aggregate (MTA). Materials and methods 40 bilateral deep carious young mandibular first permanent molars (FPMs) in 20 healthy children aged between 6 and 8 years old were randomly allocated into 2 groups in which the FPMs treated with hTDM and MTA after pulpotomy procedure. The children were followed up clinically at 3, 6, 12, and 18 months. Tomographic evaluation was performed at baseline and 18-month evaluation period. Results The overall clinical success rate was 100% in both groups. Regarding tomographic evaluation, the mean differences in root length, periapical diameter and area were statistically significant in each individual group but without statistically significant differences between both groups. Conclusion Human TDM hydrogel could be considered a promising pulpotomy agent for immature permanent teeth. Trial registration The current clinical trial was recorded at clinicaltrials.gov, NCT06116695, 27/10/2023, Retrospectively registered. |
| format | Article |
| id | doaj-art-e07379dc1ccd4a19b04513d9f44f923f |
| institution | DOAJ |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-e07379dc1ccd4a19b04513d9f44f923f2025-08-20T03:09:21ZengBMCBMC Oral Health1472-68312025-05-0125111410.1186/s12903-025-05997-1Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trialNora M. Abo Shanady0Nahed A. Abo Hamila1Gamal M. El Maghraby2Rehab F. Ghouraba3Pediatric Dentistry, Preventive Dentistry Department, Faculty of Dentistry, Oral Health, Tanta UniversityPediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta UniversityPharmaceutical Technology, Faculty of Pharmacy, Tanta UniversityOral Medicine, Periodontology, Oral Diagnosis and Radiology Department Faculty of Dentistry, Tanta UniversityAbstract Background The concept of vital pulp therapy (VPT) of immature permanent teeth has evolved in recent years. There has been a great tendency towards investigating new pulp capping materials for perfect imitation for natural dentin-pulp complex formation process and restoring the normal tissue’s characteristics. Therefore, this study aimed to assess the clinical and tomographic outcomes of apexogenesis with human treated dentin matrix (hTDM) compared to mineral trioxide aggregate (MTA). Materials and methods 40 bilateral deep carious young mandibular first permanent molars (FPMs) in 20 healthy children aged between 6 and 8 years old were randomly allocated into 2 groups in which the FPMs treated with hTDM and MTA after pulpotomy procedure. The children were followed up clinically at 3, 6, 12, and 18 months. Tomographic evaluation was performed at baseline and 18-month evaluation period. Results The overall clinical success rate was 100% in both groups. Regarding tomographic evaluation, the mean differences in root length, periapical diameter and area were statistically significant in each individual group but without statistically significant differences between both groups. Conclusion Human TDM hydrogel could be considered a promising pulpotomy agent for immature permanent teeth. Trial registration The current clinical trial was recorded at clinicaltrials.gov, NCT06116695, 27/10/2023, Retrospectively registered.https://doi.org/10.1186/s12903-025-05997-1ApexogenesisHuman treated dentin matrixYoung permanent molarsMTA |
| spellingShingle | Nora M. Abo Shanady Nahed A. Abo Hamila Gamal M. El Maghraby Rehab F. Ghouraba Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial BMC Oral Health Apexogenesis Human treated dentin matrix Young permanent molars MTA |
| title | Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial |
| title_full | Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial |
| title_fullStr | Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial |
| title_full_unstemmed | Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial |
| title_short | Tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars: a split-mouth randomized controlled clinical trial |
| title_sort | tomographic evaluation of apexogenesis with human treated dentin matrix in young permanent molars a split mouth randomized controlled clinical trial |
| topic | Apexogenesis Human treated dentin matrix Young permanent molars MTA |
| url | https://doi.org/10.1186/s12903-025-05997-1 |
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