High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis
Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2018/2989635 |
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| author | Georgios Tsinias Sofia Nikou Theodoros Papadas Panagiotis Pitsos Helen Papadaki Vasiliki Bravou |
| author_facet | Georgios Tsinias Sofia Nikou Theodoros Papadas Panagiotis Pitsos Helen Papadaki Vasiliki Bravou |
| author_sort | Georgios Tsinias |
| collection | DOAJ |
| description | Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton. Altered expression of these proteins has been implicated in human cancer. This study addresses their expression and prognostic significance in human laryngeal carcinoma. Protein expressions of cofilin, N-WASP, α-parvin, β-parvin, and PINCH1 were examined by immunohistochemistry in 72 human laryngeal squamous cell carcinomas. Correlations with clinicopathological data and survival were evaluated. All proteins examined were overexpressed in human laryngeal carcinomas compared to adjacent nonneoplastic epithelium. High expression of PINCH1 was associated significantly with high grade, lymph node-positive, and advanced stage disease. Moreover, high PINCH1 expression significantly associated with poor overall and disease-free survival and high cytoplasmic PINCH1 expression was shown by multivariate analysis to independently predict poor overall survival. In conclusion, we provide novel evidence that focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease. |
| format | Article |
| id | doaj-art-e06eaeef55564a48b7348d170e0cb621 |
| institution | OA Journals |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-e06eaeef55564a48b7348d170e0cb6212025-08-20T02:21:28ZengWileyAnalytical Cellular Pathology2210-71772210-71852018-01-01201810.1155/2018/29896352989635High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor PrognosisGeorgios Tsinias0Sofia Nikou1Theodoros Papadas2Panagiotis Pitsos3Helen Papadaki4Vasiliki Bravou5Department of Otolaryngology, Head and Neck Surgery, University Hospital of Patras, 26504 Patras, GreeceDepartment of Anatomy, Medical School of Patras, 26504 Patras, GreeceDepartment of Otolaryngology, Head and Neck Surgery, University Hospital of Patras, 26504 Patras, GreeceDepartment of Anatomy, Medical School of Patras, 26504 Patras, GreeceDepartment of Anatomy, Medical School of Patras, 26504 Patras, GreeceDepartment of Anatomy, Medical School of Patras, 26504 Patras, GreeceFocal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton. Altered expression of these proteins has been implicated in human cancer. This study addresses their expression and prognostic significance in human laryngeal carcinoma. Protein expressions of cofilin, N-WASP, α-parvin, β-parvin, and PINCH1 were examined by immunohistochemistry in 72 human laryngeal squamous cell carcinomas. Correlations with clinicopathological data and survival were evaluated. All proteins examined were overexpressed in human laryngeal carcinomas compared to adjacent nonneoplastic epithelium. High expression of PINCH1 was associated significantly with high grade, lymph node-positive, and advanced stage disease. Moreover, high PINCH1 expression significantly associated with poor overall and disease-free survival and high cytoplasmic PINCH1 expression was shown by multivariate analysis to independently predict poor overall survival. In conclusion, we provide novel evidence that focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease.http://dx.doi.org/10.1155/2018/2989635 |
| spellingShingle | Georgios Tsinias Sofia Nikou Theodoros Papadas Panagiotis Pitsos Helen Papadaki Vasiliki Bravou High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis Analytical Cellular Pathology |
| title | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis |
| title_full | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis |
| title_fullStr | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis |
| title_full_unstemmed | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis |
| title_short | High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis |
| title_sort | high pinch1 expression in human laryngeal carcinoma associates with poor prognosis |
| url | http://dx.doi.org/10.1155/2018/2989635 |
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