METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value
Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Oncology Reviews |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/or.2025.1637372/full |
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| _version_ | 1849728263618822144 |
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| author | Xinyu Zhang Yuan Chen Min Li Min Li Xiaomeng Zhou Qingcui Song Qingcui Song |
| author_facet | Xinyu Zhang Yuan Chen Min Li Min Li Xiaomeng Zhou Qingcui Song Qingcui Song |
| author_sort | Xinyu Zhang |
| collection | DOAJ |
| description | Methyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment. |
| format | Article |
| id | doaj-art-e06ba330a3a34393998017834906a8d7 |
| institution | DOAJ |
| issn | 1970-5557 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj-art-e06ba330a3a34393998017834906a8d72025-08-20T03:09:35ZengFrontiers Media S.A.Oncology Reviews1970-55572025-07-011910.3389/or.2025.16373721637372METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic valueXinyu Zhang0Yuan Chen1Min Li2Min Li3Xiaomeng Zhou4Qingcui Song5Qingcui Song6School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Precision Biomedical Key Laboratory, Liaocheng People’s Hospital, Liaocheng, Shandong, ChinaShandong Provincial Key Medical and Health Laboratory of Precision Medicine for Aging Intervention and Active Health, Liaocheng, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng, Shandong, ChinaSchool of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, ChinaDepartment of Oncology, Liaocheng People’s Hospital, Liaocheng, Shandong, ChinaMethyltransferase-like 1 (METTL1) is a methyltransferase that modulates the RNA methylation process and has been increasingly investigated in cancer research over the past decade. The review aims to summarize the diverse roles of METTL1 in various cancers, focusing on the mechanisms underlying tumorigenesis, progression, and metastasis. Furthermore, the therapeutic value and targeting strategies for METTL1 are also discussed to provide the foundation for further development of METTL1-targeted therapies. The article integrates recent research findings to highlight significant discoveries regarding METTL1, emphasizing its potential as a therapeutic target in cancer treatment.https://www.frontiersin.org/articles/10.3389/or.2025.1637372/fullMETTL1cancerRNA methylationtherapeutic targettumor mechanism |
| spellingShingle | Xinyu Zhang Yuan Chen Min Li Min Li Xiaomeng Zhou Qingcui Song Qingcui Song METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value Oncology Reviews METTL1 cancer RNA methylation therapeutic target tumor mechanism |
| title | METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value |
| title_full | METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value |
| title_fullStr | METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value |
| title_full_unstemmed | METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value |
| title_short | METTL1 in human cancers: recognition of their functions, mechanisms and therapeutic value |
| title_sort | mettl1 in human cancers recognition of their functions mechanisms and therapeutic value |
| topic | METTL1 cancer RNA methylation therapeutic target tumor mechanism |
| url | https://www.frontiersin.org/articles/10.3389/or.2025.1637372/full |
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