The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress

The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress

Abstract Telomere attrition is a hallmark of biological aging, contributing to cellular replicative senescence. However, few studies have examined the determinants of telomere attrition in vivo in humans. Mitochondrial Health Index (MHI), a composite marker integrating mitochondrial energy-transform...

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Bibliographic Details
Main Authors: Mauricio Guillen-Parra, Jue Lin, Aric A. Prather, Owen M. Wolkowitz, Martin Picard, Elissa S. Epel
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Mitochondrial health
Telomerase activity
Telomere attrition
Chronic stress
Online Access:https://doi.org/10.1038/s41598-024-77279-9
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